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Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Wang, Zhongqiu; Sturgis, Erich M; Zhang, Fenghua; Lei, Dapeng; Liu, Zhensheng; Xu, Li; Song, Xicheng; ... (9 authors) (Molecular cancer, 2012-03-26)

Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 ...

Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.

Wang, Zhongqiu; Sturgis, Erich M; Guo, Wei; Song, Xicheng; Zhang, Fenghua; Xu, Li; Wei, Qingyi; ... (8 authors) (PloS one, 2012-01)

p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis, through which inflammation/immune responses control ...