Now showing items 1-10 of 106
The genomic analysis of erythrocyte microRNA expression in sickle cell diseases.
(PLoS One, 2008-06-04)
BACKGROUND: Since mature erythrocytes are terminally differentiated cells without nuclei and organelles, it is commonly thought that they do not contain nucleic acids. In this study, we have re-examined this issue by analyzing ...
(Clin Orthop Relat Res, 2004-06)
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
(PLoS One, 2008-01-16)
BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved ...
Reported lifetime aberrant drug-taking behaviors are predictive of current substance use and mental health problems in primary care patients.
(Pain Med, 2008-11)
BACKGROUND: The aim of this report is to determine the frequency of aberrant drug behaviors and their relationship to substance abuse disorders in a large primary sample of patients receiving opioids for chronic pain. METHODS: ...
Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.
(PLoS One, 2009-12-30)
BACKGROUND: The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland ...
Development of universal antidotes to control aptamer activity.
(Nat Med, 2009-10)
With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract ...
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.
(PLoS One, 2009)
BACKGROUND: Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported. We used an integrative method to ...
Substance abuse, treatment needs and access among female sex workers and non-sex workers in Pretoria, South Africa.
(Subst Abuse Treat Prev Policy, 2009-05-27)
BACKGROUND: This study examined cross-sectional data collected from substance-using female sex workers (FSW) and non-sex workers (non-SW) in Pretoria, South Africa, who entered a randomized controlled trial. METHODS: Women ...
How actions create--not just reveal--preferences.
(Trends Cogn Sci, 2008-01)
The neo-classical economics view that behavior is driven by - and reflective of - hedonic utility is challenged by psychologists' demonstrations of cases in which actions do not merely reveal preferences but rather create ...
Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methods.
(PLoS One, 2009-08-13)
BACKGROUND: Dropouts and missing data are nearly-ubiquitous in obesity randomized controlled trails, threatening validity and generalizability of conclusions. Herein, we meta-analytically evaluate the extent of missing data, ...