Now showing items 1-10 of 21
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
(Genes Dev, 2007-04-01)
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still ...
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.
(Proc Natl Acad Sci U S A, 2007-12-26)
Brain tumors are typically resistant to conventional chemotherapeutics, most of which initiate apoptosis upstream of mitochondrial cytochrome c release. In this study, we demonstrate that directly activating apoptosis downstream ...
Gauging possibilities for action based on friction underfoot.
(J Exp Psychol Hum Percept Perform, 2007-10)
Standing and walking generate information about friction underfoot. Five experiments examined whether walkers use such perceptual information for prospective control of locomotion. In particular, do walkers integrate information ...
Should the patent system for new medicines be abolished?
(Clin Pharmacol Ther, 2007-11)
Gene expression signatures that predict radiation exposure in mice and humans.
(PLoS Med, 2007-04)
BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure ...
Shared features in the pathobiology of babesiosis and malaria.
(Trends Parasitol, 2007-12)
The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical ...
People believe it is plausible to have forgotten memories of childhood sexual abuse.
(Psychon Bull Rev, 2007-08)
Pezdek, Blandon-Gitlin, and Gabbay (2006) found that perceptions of the plausibility of events increase the likelihood that imagination may induce false memories of those events. Using a survey conducted by Gallup, we asked ...
The evolutionary origins of human patience: temporal preferences in chimpanzees, bonobos, and human adults.
(Curr Biol, 2007-10-09)
To make adaptive choices, individuals must sometimes exhibit patience, forgoing immediate benefits to acquire more valuable future rewards [1-3]. Although humans account for future consequences when making temporal decisions ...
Object files can be purely episodic.
Our ability to track an object as the same persisting entity over time and motion may primarily rely on spatiotemporal representations which encode some, but not all, of an object's features. Previous researchers using the ...
Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
(PLoS One, 2007-10-10)
BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. ...