Now showing items 1-10 of 60
Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.
(PLoS One, 2008-05-07)
BACKGROUND: Myosin VIIA (MyoVIIA) is an unconventional myosin necessary for vertebrate audition -. Human auditory transduction occurs in sensory hair cells with a staircase-like arrangement of apical protrusions called ...
(Clin Orthop Relat Res, 2004-06)
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
(Genes Dev, 2007-04-01)
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still ...
Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.
(PLoS One, 2009)
BACKGROUND: Epigenetic alterations have been implicated in the pathogenesis of solid tumors, however, proto-oncogenes activated by promoter demethylation have been sporadically reported. We used an integrative method to ...
Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm).
(J Cell Sci, 2005-05-01)
Studies in a wide variety of organisms have produced a general model for the induction of apoptosis in which multiple signaling pathways lead ultimately to activation of the caspase family of proteases. Once activated, these ...
Using decision analysis to improve malaria control policy making.
(Health Policy, 2009-10)
Malaria and other vector-borne diseases represent a significant and growing burden in many tropical countries. Successfully addressing these threats will require policies that expand access to and use of existing control ...
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
Avian brains and a new understanding of vertebrate brain evolution.
(Nat Rev Neurosci, 2005-02)
We believe that names have a powerful influence on the experiments we do and the way in which we think. For this reason, and in the light of new evidence about the function and evolution of the vertebrate brain, an international ...
Learned birdsong and the neurobiology of human language.
(Ann N Y Acad Sci, 2004-06)
Vocal learning, the substrate for human language, is a rare trait found to date in only three distantly related groups of mammals (humans, bats, and cetaceans) and three distantly related groups of birds (parrots, hummingbirds, ...
Looking past the model species: diversity in gaze-following skills across primates.
(Curr Opin Neurobiol, 2009-02)
Primates must navigate complex social landscapes in their daily lives: gathering information from and about others, competing with others for food and mates, and cooperating to obtain rewards as well. Gaze-following often ...