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The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. 

Suliman, Hagir B; Carraway, Martha Sue; Ali, Abdelwahid S; Reynolds, Chrystal M; Welty-Wolf, Karen E; Piantadosi, Claude A (J Clin Invest, 2007-12)
The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a progressive toxic cardiomyopathy linked to mitochondrial damage and cardiomyocyte apoptosis. Here we demonstrate that ...

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AuthorAli, Abdelwahid S (1)Carraway, Martha Sue (1)Piantadosi, Claude A (1)Reynolds, Chrystal M (1)Suliman, Hagir B (1)Welty-Wolf, Karen E (1)Date Issued
2007 (1)
TypeJournal article (1)Subject
3-Phosphoinositide-Dependent Protein Kinases (1)
Animals (1)Antibiotics, Antineoplastic (1)Antimetabolites (1)Apoptosis (1)
Carbon Monoxide (1)
Cardiomyopathies (1)Caspase 3 (1)Cells, Cultured (1)DNA, Mitochondrial (1)... View MoreAffiliation of Duke Author(s)Anesthesiology (1)
Clinical Science Departments (1)
Duke (1)Duke Cancer Institute (1)
Institutes and Centers (1)
Medicine (1)
Medicine, Pulmonary, Allergy, and Critical Care Medicine (1)Pathology (1)School of Medicine (1)
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