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Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults.
(The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2011-10)
Based on the multiple logistic regression analysis of data from a random sample of
1,023 old adults collected in Taiwan in 2000, we found that interactions between carrying
the APOE4 allele and one of four life stress factors ...
Gene expression in oogenesis and implications for transgenerational effects of environmental toxicants.
(Biology of reproduction, 2011-01)
TNFRSF1B +676 T>G polymorphism predicts survival of non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2011-10-14)
The dysregulation of gene expression in the TNF-TNFR superfamily has been involved
in various human cancers including non-small cell lung cancer (NSCLC). Furthermore,
functional polymorphisms in TNF-α and TNFRSF1B genes ...
Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.
(PloS one, 2011-01)
The repair of DNA double-strand breaks (DSBs) is the major mechanism to maintain genomic
stability in response to irradiation. We hypothesized that genetic polymorphisms in
DSB repair genes may affect clinical outcomes among ...
Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells.
(Journal of orthopaedic research : official publication of the Orthopaedic Research
Society, 2011-01)
Interleukin-17 (IL-17) is a cytokine recently shown to be elevated, along with interferon-γ
(IFNγ) and tumor necrosis factor (TNFα), in degenerated and herniated intervertebral
disc (IVD) tissues, suggesting a role for these ...
Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth.
(Mech Ageing Dev, 2011-04)
Recent studies have reported that leukocyte telomere length (LTL) is longer in offspring
of older fathers. Longer telomeres might increase cancer risk. We examined the relation
of father's age at the birth of the offspring ...
Exercise-induced pain intensity predicted by pre-exercise fear of pain and pain sensitivity.
(Clin J Pain, 2011-06)
OBJECTIVES: Our primary goals were to determine whether preexisting fear of pain and
pain sensitivity contributed to post-exercise pain intensity. METHODS: Delayed-onset
muscle pain was induced in the trunk extensors of ...
Hypertension and obesity as cardiovascular risk factors among HIV seropositive patients in Western Kenya.
(PLoS One, 2011)
BACKGROUND: There is increased risk of cardiovascular disease among HIV seropositive
individuals. The prevalence of HIV is highest in sub-Saharan Africa; however, HIV-related
cardiovascular risk research is largely derived ...
Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data.
(Biogerontology, 2011-04)
Small sample size of genetic data is often a limiting factor for desirable accuracy
of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic
data containing information on survival or disease ...