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Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.

Antonsen, BT; Jiang, Y; Johnson, G Allan; Leergaard, TB; Nguyen, HP; Qu, H; Sijbers, J; ... (9 authors) (Brain Struct Funct, 2013-05)

Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring ...

Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.

Archer, GE; Bigner, DD; Choi, BD; Cui, X; Flores, C; Herndon, James Emmett II; Johnson, LA; ... (12 authors) (PLoS One, 2013)

Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, ...

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Dawson, Hana Nenicka; James, Michael Lucas; Laskowitz, Daniel Todd; Lei, Beilei; Roulhac-Wilson, B; Wang, Haichen (J Neuroinflammation, 2013-08-20)

BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by specific antibodies represents a compelling ...

Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation.

Das, S; Fredrickson, Keri B; Kishnani, Priya Sunil; Sun, Baodong; Yi, Haiqing (Mol Genet Metab, 2013-07)

Previous studies strongly suggest that starch binding domain containing protein 1 (Stbd1) plays an important role in intracellular glycogen trafficking into lysosomes. We report here that Stbd1 expression is markedly increased ...