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Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.

Sanchez-Perez, Luis A; Choi, Bryan D; Archer, Gary E; Cui, Xiuyu; Flores, Catherine; Johnson, Laura A; Schmittling, Robert J; ... (12 authors) (PLoS One, 2013)

Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, ...

Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats.

Antonsen, Bjørnar T; Jiang, Yi; Veraart, Jelle; Qu, Hong; Nguyen, Huu Phuc; Sijbers, Jan; von Hörsten, Stephan; ... (9 authors) (Brain Struct Funct, 2013-05)

Rodent models of Huntington disease (HD) are valuable tools for investigating HD pathophysiology and evaluating new therapeutic approaches. Non-invasive characterization of HD-related phenotype changes is important for monitoring ...

Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation.

Yi, Haiqing; Fredrickson, Keri B; Das, Stuti; Kishnani, Priya S; Sun, Baodong (Mol Genet Metab, 2013-07)

Previous studies strongly suggest that starch binding domain containing protein 1 (Stbd1) plays an important role in intracellular glycogen trafficking into lysosomes. We report here that Stbd1 expression is markedly increased ...

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Lei, Beilei; Dawson, Hana N; Roulhac-Wilson, Briana; Wang, Haichen; Laskowitz, Daniel T; James, Michael L (J Neuroinflammation, 2013-08-20)

BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response. Antagonism of pro-inflammatory cytokines by specific antibodies represents a compelling ...