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Skewed X inactivation and survival: a 13-year follow-up study of elderly twins and singletons.
(Eur J Hum Genet, 2012-03)
In mammalian females, one of the two X chromosomes is inactivated in early embryonic
life. Females are therefore mosaics for two cell populations, one with the maternal
and one with the paternal X as the active X chromosome. ...
[More people live to be very old and with a better functioning].
(Ugeskr Laeger, 2013-10-07)
Death rates for 80+-year-olds are now half of what they were after WWII. The chance
of living past 90 years has gone up by roughly 30% per decade for people born in Denmark
in 1895, 1905, and 1915 - and the later cohorts ...
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
(Exp Gerontol, 2012-05)
Here we explore association with human longevity of common genetic variation in three
major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair
and pro/antioxidants by investigating 1273 tagging ...
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
(Ann Epidemiol, 2015-08)
PURPOSE: Familial clustering of longevity is well documented and includes both genetic
and other familial factors, but the specific underlying mechanisms are largely unknown.
We examined whether low incidence of specific ...
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
(J Gerontol A Biol Sci Med Sci, 2010-05)
BACKGROUND: Genome-wide association studies (GWAS) may yield insights into longevity.
METHODS: We performed a meta-analysis of GWAS in Caucasians from four prospective
cohort studies: the Age, Gene/Environment Susceptibi...
Cross-national comparison of sex differences in health and mortality in Denmark, Japan and the US.
(Eur J Epidemiol, 2010-07)
The present study aims to compare the direction and magnitude of sex differences in
mortality and major health dimensions across Denmark, Japan and the US. The Human
Mortality Database was used to examine sex differences ...
Sex differences in health and mortality in Moscow and Denmark.
(Eur J Epidemiol, 2014-04)
In high income countries females outlive men, although they generally report worse
health, the so-called male-female health-survival paradox. Russia has one of the world's
largest sex difference in life expectancy with a ...
Optimism and survival: does an optimistic outlook predict better survival at advanced ages? A twelve-year follow-up of Danish nonagenarians.
(Aging Clin Exp Res, 2013-10)
BACKGROUND AND AIMS: Studies examining predictors of survival among the oldest-old
have primarily focused on objective measures, such as physical function and health
status. Only a few studies have examined the effect of ...
Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
(Aging (Albany NY), 2011-01)
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559)
were examined and compared to individuals from other cohorts to determine whether
the recruitment targeting longevity resulted in a cohort ...
Physical and mental decline and yet rather happy? A study of Danes aged 45 and older.
(Aging Ment Health, 2015)
OBJECTIVES: Little is known about whether the feeling of happiness follows the age-related
decline in physical and mental functioning. The objective of this study was to analyze
differences with age in physical and mental ...