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Interstitial engraftment of adipose-derived stem cells into an acellular dermal matrix results in improved inward angiogenesis and tissue incorporation. 

Erdmann, D; Hollenbeck, ST; Klitzman, Bruce; Komatsu, I; Levin, LS; Yang, J; Zhang, Y (J Biomed Mater Res A, 2013-10)
Acellular dermal matrices (ADM) are commonly used in reconstructive procedures and rely on host cell invasion to become incorporated into host tissues. We investigated different approaches to adipose-derived stem cells (ASCs) ...
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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 

Boyce, Michael; Bryant, Kevin F; Jousse, Céline; Long, Kai; Harding, Heather P; Scheuner, Donalyn; Kaufman, Randal J; ... (11 authors) (Science (New York, N.Y.), 2005-02)
Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect ...
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Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection. 

Bráz, João M; Wang, Fan; Basbaum, Allan I (PLoS One, 2015)
Although neuroanatomical tracing studies have defined the origin and targets of major projection neurons (PN) of the central nervous system (CNS), there is much less information about the circuits that influence these neurons. ...
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A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 

Gu, Bin; Huang, Yang Zhong; He, Xiao-Ping; Joshi, Rasesh B; Jang, Wonjo; McNamara, James O (Neuron, 2015-11-04)
The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing ...
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Kinematic and dynamic gait compensations in a rat model of lumbar radiculopathy and the effects of tumor necrosis factor-alpha antagonism. 

Allen, Kyle D; Shamji, Mohammed F; Mata, Brian A; Gabr, Mostafa A; Sinclair, S Michael; Schmitt, Daniel O; Richardson, William J; ... (8 authors) (Arthritis research & therapy, 2011-08-26)
Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that TNF antagonists can attenuate ...
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Intravital microscopy evaluation of angiogenesis and its effects on glucose sensor performance. 

Koschwanez, HE; Reichert, WM; Klitzman, B (J Biomed Mater Res A, 2010-06-15)
An optical window model for the rodent dorsum was used to perform chronic and quantitative intravital microscopy and laser Doppler flowmetry of microvascular networks adjacent to functional and non-functional glucose sensors. ...
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Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model. 

Stroncek, JD; Ren, LC; Klitzman, B; Reichert, WM (Acta Biomater, 2012-01)
Late outgrowth endothelial progenitor cells (EPCs) derived from the peripheral blood of patients with significant coronary artery disease were sodded into the lumens of small diameter expanded polytetrafluoroethylene (ePTFE) ...
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Increased in vivo glucose recovery via nitric oxide release. 

Nichols, Scott P; Le, Nga N; Klitzman, Bruce; Schoenfisch, Mark H (Anal Chem, 2011-02-15)
The in vivo glucose recovery of subcutaneously implanted nitric oxide (NO)-releasing microdialysis probes was evaluated in a rat model using saturated NO solutions to steadily release NO. Such methodology resulted in a constant ...
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Induction of anti-myelin antibodies in EAE and their possible role in demyelination. 

Sadler, RH; Sommer, MA; Forno, LS; Smith, ME (J Neurosci Res, 1991-12)
Experimental allergic encephalomyelitis is characterized by invasion of lymphocytes and macrophages into the central nervous system resulting in inflammation, edema, and demyelination. Sera from Lewis rats from 7-95 days ...
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Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. 

Ribeiro, Sidarta; Mello, Claudio V; Velho, Tarciso; Gardner, Timothy J; Jarvis, Erich D; Pavlides, Constantine (J Neurosci, 2002-12-15)
Rapid-eye-movement (REM) sleep plays a key role in the consolidation of memories acquired during waking (WK). The search for mechanisms underlying that role has revealed significant correlations in the patterns of neuronal ...
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AuthorKlitzman, Bruce (5)Erdmann, Detlev (3)Allen, Kyle D (2)Gabr, Mostafa A (2)Hollenbeck, Scott T (2)Klitzman, B (2)Komatsu, Issei (2)Levin, LS (2)Mata, Brian A (2)Nicolelis, Miguel AL (2)... View MoreDate Issued2010 - 2015 (22)2000 - 2009 (3)1991 - 1999 (2)TypeJournal article (27)Subject
Animals (27)
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Rats (27)
Rats, Sprague-Dawley (9)Mice (7)Humans (6)Cells, Cultured (5)Rats, Inbred Lew (5)Disease Models, Animal (4)Adaptation, Physiological (3)... View MoreAffiliation of Duke Author(s)Duke (27)School of Medicine (27)Clinical Science Departments (22)Basic Science Departments (19)Institutes and Centers (11)Cell Biology (10)Duke Cancer Institute (9)Institutes and Provost's Academic Units (9)Surgery (9)Duke Institute for Brain Sciences (8)... View More
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