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Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 

Meloni, Alison R; Fralish, Gregory B; Kelly, Patrick; Salahpour, Ali; Chen, James K; Wechsler-Reya, Robert J; Lefkowitz, Robert J; ... (8 authors) (Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...

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AuthorCaron, Marc G (1)Chen, James K (1)Fralish, Gregory B (1)Kelly, Patrick (1)Lefkowitz, Robert J (1)Meloni, Alison R (1)Salahpour, Ali (1)Wechsler-Reya, Robert J (1)Date Issued
2006 (1)
TypeJournal article (1)Subject
Animals (1)
Arrestins (1)beta-Adrenergic Receptor Kinases (1)beta-Arrestin 2 (1)
beta-Arrestins (1)
Cattle (1)Cell Line (1)Humans (1)Mice (1)Oncogene Proteins (1)... View MoreAffiliation of Duke Author(s)Basic Science Departments (1)Biochemistry (1)Cell Biology (1)Chemistry (1)
Clinical Science Departments (1)
Duke (1)Duke Cancer Institute (1)Duke Institute for Brain Sciences (1)Faculty (1)
Institutes and Centers (1)
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