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Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group.
(PloS one, 2018-01)
Changes in levels of cytokines and chemokines have been proposed as possible biomarkers
of tissue injury, including liver injury due to drugs. Recently, in acute drug-induced
liver injury (DILI), we showed that 19 of 27 ...
Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations.
(Hepatology (Baltimore, Md.), 2014-02)
Drug-induced liver injury (DILI) is considered to be a diagnosis of exclusion. Liver
biopsy may contribute to diagnostic accuracy, but the histological features of DILI
and their relationship to biochemical parameters and ...
Differential prevalence and geographic distribution of hepatitis C virus genotypes in acute and chronic hepatitis C patients in Vietnam.
(PloS one, 2019-01)
BACKGROUND:The highest burden of disease from hepatitis C virus (HCV) is found in
Southeast Asia, but our understanding of the epidemiology of infection in many heavily
burdened countries is still limited. In particular, ...
Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection?
(Ann Neurol, 2015-04)
OBJECTIVE: A study was undertaken to determine whether better cognitive functioning
at midlife among more physically fit individuals reflects neuroprotection, by which
fitness protects against age-related cognitive decline, ...
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
(Ann Epidemiol, 2015-08)
PURPOSE: Familial clustering of longevity is well documented and includes both genetic
and other familial factors, but the specific underlying mechanisms are largely unknown.
We examined whether low incidence of specific ...
Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.
(Clin Infect Dis, 2015-11-01)
BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with
a compatible clinical illness, but the significance of positive test results in low-prevalence
regions has not been investigated. METHODS: ...
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
(Am J Respir Crit Care Med, 2014-08-15)
RATIONALE: Asthma is prospectively associated with age-related chronic diseases and
mortality, suggesting the hypothesis that asthma may relate to a general, multisystem
phenotype of accelerated aging. OBJECTIVES: To test ...
Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa.
(Clin Infect Dis, 2015-11-01)
BACKGROUND: The clinical diagnosis of bacterial bloodstream infections (BSIs) in sub-Saharan
Africa is routinely confused with malaria due to overlapping symptoms. The Typhoid
Surveillance in Africa Program (TSAP) recruited ...