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Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
(BMC cancer, 2016-02-08)
FAS/FASL promoter variants are considered in altering transcriptional activity of
those genes and consequently alter regulation of cell death. However, no studies have
investigated whether tumor sites contribute ...
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)
Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since
prior studies have supported a genetic basis for postoperative AKI, we conducted a
genome-wide association study (GWAS) for AKI following ...
Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms.
(Breast Cancer Res Treat, 2011-07)
The observed bimodal patterns of breast cancer incidence in the U.S. suggested that
breast cancer may be viewed as more than one biological entity. We studied the factors
potentially contributing to this phenomenon, specifically ...
Effect of socioeconomic status as measured by education level on survival in breast cancer clinical trials.
(Psychooncology, 2013-02)
OBJECTIVES: This paper aims to investigate the effect of socioeconomic status, as
measured by education, on the survival of breast cancer patients treated on 10 studies
conducted by the Cancer and Leukemia Group B. METHODS: ...
Preoperative predictors of extended hospital length of stay following total knee arthroplasty.
(J Arthroplasty, 2015-03)
The purpose of this study was to identify the preoperative predictors of hospital
length of stay after primary total knee arthroplasty in a patient population reflecting
current trends toward shorter hospitalization and ...
Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.
(J Am Heart Assoc, 2013-11-25)
BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis
in atrial fibrillation. Adoption patterns of this new agent in community practice
are unknown. METHODS AND RESULTS: We studied patterns ...
Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: study rationale, development and design.
(BMC Health Serv Res, 2012-01-18)
BACKGROUND: Type 2 diabetes is a prevalent chronic condition globally that results
in extensive morbidity, decreased quality of life, and increased health services utilization.
Lifestyle changes can prevent the development ...
How Reliable are Patient-Reported Rehospitalizations? Implications for the Design of Future Practical Clinical Studies.
(J Am Heart Assoc, 2016-01-25)
BACKGROUND: Longitudinal clinical investigations often rely on patient reports to
screen for postdischarge adverse outcomes events, yet few studies have examined the
accuracy of such patient reports. METHODS AND RESULTS: ...
The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation.
(Eur Heart J, 2015-12-07)
BACKGROUND: Therapeutic decisions in atrial fibrillation (AF) are often influenced
by assessment of bleeding risk. However, existing bleeding risk scores have limitations.
OBJECTIVES: We sought to develop and validate a ...