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Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.
(PloS one, 2012-01)
Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important
role in nucleotide excision repair and participates in removal of DNA interstrand
cross-links and DNA double-strand breaks. Single nucleotide ...
Hypertension and obesity as cardiovascular risk factors among HIV seropositive patients in Western Kenya.
(PLoS One, 2011)
BACKGROUND: There is increased risk of cardiovascular disease among HIV seropositive
individuals. The prevalence of HIV is highest in sub-Saharan Africa; however, HIV-related
cardiovascular risk research is largely derived ...
Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records.
(BMC Infect Dis, 2014-05-22)
BACKGROUND: Mortality among people with human immunodeficiency virus (HIV) infection
is increasingly due to non-communicable causes. This has been observed mostly in developed
countries and the routine care of HIV infected ...
Safety and efficacy of ledipasvir-sofosbuvir in black patients with hepatitis C virus infection: A retrospective analysis of phase 3 data.
(Hepatology, 2016-02)
UNLABELLED: Black patients chronically infected with genotype 1 hepatitis C virus
(HCV) have historically had lower rates of response to interferon-based treatment
than patients of other races. In the phase 3 ION program, ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.
(Clin Infect Dis, 2012-07)
BACKGROUND: Disseminated tuberculosis is a major health problem in countries where
generalized human immunodeficiency virus (HIV) infection epidemics coincide with high
tuberculosis incidence rates; data are limited on patient ...
Patterns of care quality and prognosis among hospitalized ischemic stroke patients with chronic kidney disease.
(J Am Heart Assoc, 2014-06-05)
BACKGROUND: Relatively little is known about the quality of care and outcomes for
hospitalized ischemic stroke patients with chronic kidney disease (CKD). We examined
quality of care and in-hospital prognoses among patients ...
Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection.
(Clin Infect Dis, 2010-09-15)
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of
complicated skin and skin-structure infection (cSSSI). Increasing antimicrobial resistance
in cSSSI has led to a need for new safe and effective ...