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Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.

Liu, Zhensheng; Wei, Qingyi; Yu, Hongping; Huang, Yu-Jing; Yin, Ming; Wang, Li-E (PloS one, 2012-01)

Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide ...

Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.

Liu, Zhensheng; Wei, Qingyi; Yin, Jieyun; Liu, Hongliang; Wang, Li-E; Chen, Wei V; Zhu, Dakai; ... (10 authors) (The Journal of investigative dermatology, 2015-02)

Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association ...

Host gene expression classifiers diagnose acute respiratory illness etiology.

Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)

Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...

Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.

Bancroft-Wu, V; Batrachenko, A; De Bellis, MD; Langkammer, C; Li, W; Liu, C; Morey, Rajendra A; ... (11 authors) (Hum Brain Mapp, 2014-06)

As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve ...

Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.

Bartlett, John A; Chow, S-C; Crump, John Andrew; Maro, Venance P; Morrissey, AB; Mushi, GS; Mwako, MS; ... (12 authors) (Clin Infect Dis, 2012-07)

BACKGROUND: Disseminated tuberculosis is a major health problem in countries where generalized human immunodeficiency virus (HIV) infection epidemics coincide with high tuberculosis incidence rates; data are limited on patient ...

Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.

Zhang, W; Liu, H; Liu, Z; Zhu, D; Amos, CI; Fang, S; Lee, JE; ... (8 authors) (Cancer Epidemiol Biomarkers Prev, 2015-07)

BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous melanoma to promote growth and aggressive metastatic potential of primary melanoma cells. Therefore, genetic variants in Notch pathway ...

Leptospirosis among hospitalized febrile patients in northern Tanzania.

Bartlett, John A; Biggs, HM; Bui, DM; Crump, John Andrew; Galloway, RL; Kinabo, GD; Maro, Venance P; ... (12 authors) (Am J Trop Med Hyg, 2011-08)

We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal ...

Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.

Arachchi, WK; Bodinayake, Champica K; Dabrera, T; Nagahawatte, A; Østbye, Truls; Sooriyaarachchi, A; Stewart, K; ... (10 authors) (BMC Fam Pract, 2018-03-01)

BACKGROUND: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka ...

Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.

Bartlett, John A; Crump, John Andrew; Maro, Venance P; Rubach, MP (Am J Trop Med Hyg, 2015-02)

We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ...

Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study.

Bartlett, John A; Crump, John Andrew; Galloway, RL; Kinabo, GD; Maro, Venance P; Massung, RF; Morrissey, AB; ... (12 authors) (PLoS Negl Trop Dis, 2013)

INTRODUCTION: The syndrome of fever is a commonly presenting complaint among persons seeking healthcare in low-resource areas, yet the public health community has not approached fever in a comprehensive manner. In many areas, ...