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Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.
(PloS one, 2012-01)
Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important
role in nucleotide excision repair and participates in removal of DNA interstrand
cross-links and DNA double-strand breaks. Single nucleotide ...
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.
(BMC cancer, 2012-05)
The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and
myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human
papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...
Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.
(J Hematol Oncol, 2018-03-04)
BACKGROUND: The binding of CXCR4 with its ligand (stromal-derived factor-1) maintains
hematopoietic stem/progenitor cells (HSPCs) in a quiescent state. We hypothesized
that blocking CXCR4/SDF-1 interaction after hematopoietic ...
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
(Hum Brain Mapp, 2014-06)
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve ...
Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.
(Clin Infect Dis, 2012-07)
BACKGROUND: Disseminated tuberculosis is a major health problem in countries where
generalized human immunodeficiency virus (HIV) infection epidemics coincide with high
tuberculosis incidence rates; data are limited on patient ...
Polymorphisms in Fibronectin Binding Proteins A and B among Staphylococcus aureus Bloodstream Isolates Are Not Associated with Arthroplasty Infection.
(PLoS One, 2015)
BACKGROUND: Nonsynonymous single nucleotide polymorphisms (SNPs) in fibronectin binding
protein A (fnbA) of Staphylococcus aureus are associated with cardiac device infections.
However, the role of fnbA SNPs in S. aureus ...
Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone.
(Bone Marrow Transplant, 2013-11)
Chemotherapy plus G-CSF (C+G) and G-CSF alone are two of the most common methods used
to mobilize CD34(+) cells for autologous hematopoietic SCT (AHSCT). In order to compare
and determine the real-world outcomes and costs ...
A phase I study of ABT-510 plus bevacizumab in advanced solid tumors.
(Cancer Med, 2013-06)
Targeting multiple regulators of tumor angiogenesis have the potential to improve
treatment efficacy. Bevacizumab is a monoclonal antibody directed against vascular
endothelial growth factor and ABT-510 is a synthetic analog ...