Search

Now showing items 1-10 of 13

Host gene expression classifiers diagnose acute respiratory illness etiology.

Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)

Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...

Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.

Bancroft-Wu, V; Batrachenko, A; De Bellis, MD; Langkammer, C; Li, W; Liu, C; Morey, Rajendra A; ... (11 authors) (Hum Brain Mapp, 2014-06)

As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve ...

Bacteremic disseminated tuberculosis in sub-saharan Africa: a prospective cohort study.

Bartlett, John A; Chow, S-C; Crump, John Andrew; Maro, Venance P; Morrissey, AB; Mushi, GS; Mwako, MS; ... (12 authors) (Clin Infect Dis, 2012-07)

BACKGROUND: Disseminated tuberculosis is a major health problem in countries where generalized human immunodeficiency virus (HIV) infection epidemics coincide with high tuberculosis incidence rates; data are limited on patient ...

Changes in HIV risk behavior and seroincidence among clients presenting for repeat HIV counseling and testing in Moshi, Tanzania.

Crump, John Andrew; Fiorillo, SP; Itemba, DK; Landman, KZ; Mtalo, A; Ostermann, Jan; Thielman, Nathan Maclyn; ... (8 authors) (AIDS Care, 2012)

While HIV counseling and testing (HCT) has been considered an HIV preventive measure in Africa, data are limited describing behavior changes following HCT. This study evaluated behavior changes and estimated HIV seroincidence ...

Integrated analysis of CANVAS 1 and 2: phase 3, multicenter, randomized, double-blind studies to evaluate the safety and efficacy of ceftaroline versus vancomycin plus aztreonam in complicated skin and skin-structure infection.

Corey, GR; Wilcox, M; Talbot, GH; Friedland, HD; Baculik, T; Witherell, GW; Critchley, I; ... (9 authors) (Clin Infect Dis, 2010-09-15)

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of complicated skin and skin-structure infection (cSSSI). Increasing antimicrobial resistance in cSSSI has led to a need for new safe and effective ...

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.

Auwaerter, PG; Boggan, Joel; Branda, JA; Chudgar, Saumil; Fowler, Vance Garrison Jr; Lantos, Paul; Nigrovic, LE; ... (9 authors) (Clin Infect Dis, 2015-11-01)

BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS: ...

Adult age differences in functional connectivity during executive control.

Madden, David Joseph; Costello, MC; Dennis, NA; Davis, Simon Wilton; Shepler, AM; Spaniol, J; Bucur, B; ... (8 authors) (Neuroimage, 2010-08-15)

Task switching requires executive control processes that undergo age-related decline. Previous neuroimaging studies have identified age-related differences in brain activation associated with global switching effects (dual-task ...

Leptospirosis among hospitalized febrile patients in northern Tanzania.

Bartlett, John A; Biggs, HM; Bui, DM; Crump, John Andrew; Galloway, RL; Kinabo, GD; Maro, Venance P; ... (12 authors) (Am J Trop Med Hyg, 2011-08)

We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal ...

Antibiotic overuse for acute respiratory tract infections in Sri Lanka: a qualitative study of outpatients and their physicians.

Arachchi, WK; Bodinayake, Champica K; Dabrera, T; Nagahawatte, A; Østbye, Truls; Sooriyaarachchi, A; Stewart, K; ... (10 authors) (BMC Fam Pract, 2018-03-01)

BACKGROUND: Acute respiratory tract infections (ARTIs) are a common reason for antibiotic overuse worldwide. We previously showed that over 80% of outpatients presenting to a tertiary care hospital in Sri Lanka ...

Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.

Bartlett, John A; Crump, John Andrew; Maro, Venance P; Rubach, MP (Am J Trop Med Hyg, 2015-02)

We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ...