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Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 

Glower, Donald D Jr; Hata, Jonathan Andrew; Koch, Walter J; Kypson, Alan P; Lefkowitz, Robert J; Lilly, R Eric; Pippen, Anne; ... (10 authors) (Circulation, 2000-02-01)
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
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Meningococcemia in a patient coinfected with hepatitis C virus and HIV. 

Nelson, CG; Iler, MA; Woods, CW; Bartlett, JA; Fowler, VG (Emerg Infect Dis, 2000-11)
We describe the first reported case of meningococcemia in a patient coinfected with hepatitis C virus and HIV. Hypocomplementemia secondary to hepatic dysfunction may have enhanced the patient's susceptibility to meningococcal ...
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Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 

Claing, A; Perry, SJ; Achiriloaie, M; Walker, JK; Albanesi, JP; Lefkowitz, RJ; Premont, RT (Proc Natl Acad Sci U S A, 2000-02-01)
Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled ...
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Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. 

White, DC; Hata, JA; Shah, AS; Glower, DD; Lefkowitz, RJ; Koch, WJ (Proc Natl Acad Sci U S A, 2000-05-09)
When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac inotropic reserve. betaAR down-regulation and functional ...
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Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. 

Smith, JJ; Evans, EK; Murakami, M; Moyer, MB; Moseley, MA; Vande Woude, G; Kornbluth, S (J Cell Biol, 2000-12-25)
Many of the biochemical reactions of apoptotic cell death, including mitochondrial cytochrome c release and caspase activation, can be reconstituted in cell-free extracts derived from Xenopus eggs. In addition, because caspase ...
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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. 

Eckhart, AD; Duncan, SJ; Penn, RB; Benovic, JL; Lefkowitz, RJ; Koch, WJ (Circ Res, 2000-01-07)
G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization. In vivo analysis of GRK substrate selectivity has ...
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Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 

Pierce, KL; Maudsley, S; Daaka, Y; Luttrell, LM; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 2000-02-15)
Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs) activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade. Recently, it has been shown ...
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Catecholamines, cardiac beta-adrenergic receptors, and heart failure. 

Lefkowitz, RJ; Rockman, HA; Koch, WJ (Circulation, 2000-04-11)
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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. 

Maudsley, S; Zamah, AM; Rahman, N; Blitzer, JT; Luttrell, LM; Lefkowitz, RJ; Hall, RA (Mol Cell Biol, 2000-11)
Platelet-derived growth factor (PDGF) is a potent mitogen for many cell types. The PDGF receptor (PDGFR) is a receptor tyrosine kinase that mediates the mitogenic effects of PDGF by binding to and/or phosphorylating a variety ...

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AuthorLefkowitz, RJ (6)Koch, WJ (3)Luttrell, LM (2)Maudsley, S (2)Shah, AS (2)Achiriloaie, M (1)Albanesi, JP (1)Bartlett, JA (1)Benovic, JL (1)Blitzer, JT (1)... View MoreDate Issued
2000 (9)
Type
Journal article (9)
SubjectAnimals (8)Humans (5)Myocardium (4)Receptors, Adrenergic, beta (4)Mitogen-Activated Protein Kinases (3)Phosphorylation (3)Adenoviridae (2)beta-Adrenergic Receptor Kinases (2)Cell Cycle Proteins (2)COS Cells (2)... View MoreAffiliation of Duke Author(s)
Clinical Science Departments (9)
Duke (9)
Duke Cancer Institute (9)
Institutes and Centers (9)
Medicine (9)
School of Medicine (9)Basic Science Departments (8)Medicine, Cardiology (8)Pathology (8)Trinity College of Arts & Sciences (8)... View More
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