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Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. 

Glower, Donald D Jr; Hata, Jonathan Andrew; Koch, Walter J; Kypson, Alan P; Lefkowitz, Robert J; Lilly, R Eric; Pippen, Anne; ... (10 authors) (Circulation, 2000-02-01)
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
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Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
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Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 

Bohn, Laura M; Gainetdinov, Raul R; Sotnikova, Tatyana D; Medvedev, Ivan O; Lefkowitz, Robert J; Dykstra, Linda A; Caron, Marc G (J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...
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Construct and differential item functioning in the assessment of prescription opioid use disorders among American adolescents. 

Wu, Li-Tzy; Ringwalt, Christopher L; Yang, Chongming; Reeve, Bryce B; Pan, Jeng-Jong; Blazer, Dan G (Journal of the American Academy of Child and Adolescent Psychiatry, 2009-05)
OBJECTIVE:To examine the psychometric properties of diagnostic criteria for prescription analgesic opioid use disorders (OUDs) and to identify background predictors of a latent continuum for OUD liability. METHOD:Data were ...
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Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. 

Levesque, Marc C; Moody, M Anthony; Hwang, Kwan-Ki; Marshall, Dawn J; Whitesides, John F; Amos, Joshua D; Gurley, Thaddeus C; ... (25 authors) (PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks ...
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Beta-arrestin-2 regulates the development of allergic asthma. 

Walker, Julia KL; Fong, Alan M; Lawson, Barbara L; Savov, Jordan D; Patel, Dhavalkumar D; Schwartz, David A; Lefkowitz, Robert J (J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...
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Reported lifetime aberrant drug-taking behaviors are predictive of current substance use and mental health problems in primary care patients. 

Fleming, Michael F; Davis, James; Passik, Steven D (Pain Med, 2008-11)
BACKGROUND: The aim of this report is to determine the frequency of aberrant drug behaviors and their relationship to substance abuse disorders in a large primary sample of patients receiving opioids for chronic pain. METHODS: ...
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Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population. 

Yang, Miao; Wu, Tangchun; Cheng, Longxian; Wang, Feng; Wei, Qingyi; Tanguay, Robert M (Respiratory research, 2005-01)
BACKGROUND: The heat shock proteins (Hsps) are induced by stresses such as allergic factors and inflammatory responses in bronchi epithelial cells and therefore may be detectable in patients with asthma. However, the etiologic ...
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Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. 

Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tan, Dongfeng; Ajani, Jaffer A; Wei, Qingyi (Journal of experimental & clinical cancer research : CR, 2009-06-30)
Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that ...
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The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. 

Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tang, Dongfeng; Ajani, Jaffer A; Wei, Qingyi (BMC gastroenterology, 2009-10-16)
Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression ...
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AuthorLefkowitz, Robert J (4)Koch, WJ (3)Lefkowitz, RJ (3)Shah, AS (3)Wei, Qingyi (3)Ajani, Jaffer A (2)Bartlett, John A (2)Crump, John A (2)Ginsburg, Geoffrey S (2)Glower, DD (2)... View MoreDate Issued2009 (9)2008 (6)2003 (3)2000 (2)2001 (2)2004 (2)2005 (1)2007 (1)Type
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