Search

Now showing items 1-8 of 8

Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft.

Burlingham, WJ; Farris, AB; Knechtle, Stuart J; Kwun, J; Mahle, WT; Song, H (Transplantation, 2015-12)

BACKGROUND: Blocking leukocyte function-associated antigen (LFA)-1 in organ transplant recipients prolongs allograft survival. However, the precise mechanisms underlying the therapeutic potential of LFA-1 blockade in preventing ...

Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques.

Gibby, Adriana C; Hennigar, RA; Iwakoshi, Neal N; Jenkins, JB; Knechtle, Stuart J; Kwun, J; Leopardi, F; ... (11 authors) (Am J Transplant, 2012-09)

Chronic allograft rejection is a major impediment to long-term transplant success. Humoral immune responses to alloantigens are a growing clinical problem in transplantation, with mounting evidence associating alloantibodies ...

Interleukin-15 receptor blockade in non-human primate kidney transplantation.

Faure, JP; Fechner, J; Haustein, S; Kayaoglu, A; Knechtle, Stuart J; Kwun, J; Roenneburg, D; ... (8 authors) (Transplantation, 2010-04-27)

BACKGROUND: Interleukin (IL)-15 is a chemotactic factor to T cells. It induces proliferation and promotes survival of activated T cells. IL-15 receptor blockade in mouse cardiac and islet allotransplant models has led to ...

Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation.

Burlingham, WJ; Knechtle, Stuart J; Kwun, J; Malarkannan, S (J Immunol, 2011-10-15)

Grafts can be rejected even when matched for MHC because of differences in the minor histocompatibility Ags (mH-Ags). H4- and H60-derived epitopes are known as immunodominant mH-Ags in H2(b)-compatible BALB.B to C57BL/6 ...

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Farris, AB; Gibby, Adriana C; Hong, JJ; Knechtle, Stuart J; Kwun, J; Page, EK; Villinger, F; ... (8 authors) (Am J Transplant, 2015-03)

Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical ...

The role of B cells in solid organ transplantation.

Bulut, P; Dar, W; Iwakoshi, Neal N; Kim, E; Knechtle, Stuart J; Kwun, J; Oh, B; ... (8 authors) (Semin Immunol, 2012-04)

The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning ...

Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.

Bulut, OP; Farris, AB; Gibby, Adriana C; Iwakoshi, Neal N; Kim, DW; Kirk, Allan D; Knechtle, Stuart J; ... (13 authors) (Am J Transplant, 2012-10)

Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody-mediated mechanisms during CR are poorly ...

Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.

Farris, AB; Gibby, Adriana C; Hong, JJ; Iwakoshi, Neal N; Kim, EJ; Kirk, Allan D; Knechtle, Stuart J; ... (9 authors) (Am J Transplant, 2014-01)

De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion using anti-CD3 immunotoxin combined with ...