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Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA predict melanoma survival.

Liu, Zhensheng; Wei, Qingyi; Yin, Jieyun; Liu, Hongliang; Wang, Li-E; Chen, Wei V; Zhu, Dakai; ... (10 authors) (The Journal of investigative dermatology, 2015-02)

Cutaneous melanoma (CM) is the most lethal skin cancer. The Fanconi anemia (FA) pathway involved in DNA crosslink repair may affect CM susceptibility and prognosis. Using data derived from published genome-wide association ...

Baseline EEG pattern on continuous ICU EEG monitoring and incidence of seizures.

Husain, AM; Shah, D; Sinha, SR; Swisher, Christa Brittany (J Clin Neurophysiol, 2015-04)

PURPOSE: To identify the probability of detecting nonconvulsive seizures based on the initial pattern seen in the first 30 minutes of continuous EEG (cEEG) monitoring. METHODS: Continuous EEG monitoring reports from 243 ...

Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.

Bartlett, John A; Crump, John Andrew; Grossmann, H; Masenga, EJ; Mavura, DR; Minja, E (Int J Dermatol, 2015-01)

Abnormal skin findings are identified in over 90% of human immunodeficiency virus (HIV)-infected persons globally. A prospective cohort study of HIV-infected patients with skin complaints commencing antiretroviral therapy ...

Poor Positive Predictive Value of Lyme Disease Serologic Testing in an Area of Low Disease Incidence.

Auwaerter, PG; Boggan, Joel; Branda, JA; Chudgar, Saumil; Fowler, Vance Garrison Jr; Lantos, Paul; Nigrovic, LE; ... (9 authors) (Clin Infect Dis, 2015-11-01)

BACKGROUND: Lyme disease is diagnosed by 2-tiered serologic testing in patients with a compatible clinical illness, but the significance of positive test results in low-prevalence regions has not been investigated. METHODS: ...

Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.

Zhang, W; Liu, H; Liu, Z; Zhu, D; Amos, CI; Fang, S; Lee, JE; ... (8 authors) (Cancer Epidemiol Biomarkers Prev, 2015-07)

BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous melanoma to promote growth and aggressive metastatic potential of primary melanoma cells. Therefore, genetic variants in Notch pathway ...

Etiologies of illness among patients meeting integrated management of adolescent and adult illness district clinician manual criteria for severe infections in northern Tanzania: implications for empiric antimicrobial therapy.

Bartlett, John A; Crump, John Andrew; Maro, Venance P; Rubach, MP (Am J Trop Med Hyg, 2015-02)

We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness ...

TNF rs1799964 as a Predictive Factor of Acute Toxicities in Chinese Rectal Cancer Patients Treated With Chemoradiotherapy.

Wei, Qingyi; Zhang, Hui; Wang, Mengyun; Shi, Tingyan; Shen, Lijun; Liang, Liping; Deng, Yun; ... (13 authors) (Medicine, 2015-11)

Acute toxicity is the main dose-limiting factor in the chemoradiotherapy of rectal cancer patients and depends on several pro-inflammatory factors, including interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-α). ...