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Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population. 

Li, Qiaoxin; Gu, Chengyuan; Zhu, Yao; Wang, Mengyun; Yang, Yajun; Wang, Jiucun; Jin, Li; ... (13 authors) (PloS one, 2013-01)
BACKGROUND: The mTOR gene regulates cell growth by controlling mRNA translation, ribosome biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was associated with carcinogenesis, and its functional ...
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Polymorphisms of nucleotide excision repair genes predict melanoma survival. 

Li, Chunying; Yin, Ming; Wang, Li-E; Amos, Christopher I; Zhu, Dakai; Lee, Jeffrey E; Gershenwald, Jeffrey E; ... (9 authors) (The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair (NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients, we evaluated whether genetic variants of NER genes ...
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Gender and age interact to affect early outcome after intracerebral hemorrhage. 

Umeano, Odera; Phillips-Bute, Barbara; Hailey, Claire E; Sun, Wei; Gray, Marisa C; Roulhac-Wilson, Briana; McDonagh, David L; ... (10 authors) (PLoS One, 2013)
BACKGROUND: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological ...
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Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation. 

Steinberg, Benjamin A; Holmes, Dajuanicia N; Piccini, Jonathan P; Ansell, Jack; Chang, Paul; Fonarow, Gregg C; Gersh, Bernard; ... (15 authors) (J Am Heart Assoc, 2013-11-25)
BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis in atrial fibrillation. Adoption patterns of this new agent in community practice are unknown. METHODS AND RESULTS: We studied patterns ...
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Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study. 

Moehring, Rebekah W; Sloane, Richard; Chen, Luke F; Smathers, Emily C; Schmader, Kenneth E; Fowler, Vance G; Weber, David J; ... (9 authors) (PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition with estimated 30% mortality. Clinical outcomes for patients with severe infections improve when antibiotics are appropriately chosen ...
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Biomarkers to help guide management of patients with pulmonary nodules. 

Patz, Edward F; Campa, Michael J; Gottlin, Elizabeth B; Trotter, Priscilla R; Herndon, James E; Kafader, Don; Grant, Russell P; ... (8 authors) (Am J Respir Crit Care Med, 2013-08-15)
RATIONALE: Indeterminate pulmonary nodules are a common radiographic finding and require further evaluation because of the concern for lung cancer. OBJECTIVES: We developed an algorithm to assign patients to a low- or high-risk ...
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Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma. 

Lou, Emil; Peters, Katherine B; Sumrall, Ashley L; Desjardins, Annick; Reardon, David A; Lipp, Eric S; Herndon, James E; ... (12 authors) (Cancer Med, 2013-04)
Patients with unresectable glioblastomas have a poor prognosis, with median survival of 6-10 months. We conducted a phase II trial of upfront 5-day temozolomide (TMZ) and bevacizumab (BV) in patients with newly diagnosed ...
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Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. 

Scialla, Julia J; Lau, Wei Ling; Reilly, Muredach P; Isakova, Tamara; Yang, Hsueh-Ying; Crouthamel, Matthew H; Chavkin, Nicholas W; ... (23 authors) (Kidney international, 2013-06)
Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in patients with chronic kidney disease. As a potential mediating mechanism, FGF23 induces left ventricular hypertrophy; however, its ...
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Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. 

Wang, Meng-Yun; Zhu, Mei-Ling; He, Jing; Shi, Ting-Yan; Li, Qiao-Xin; Wang, Ya-Nong; Li, Jin; ... (14 authors) (PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. However, few studies have evaluated associations between functional ...
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Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. 

Jin, Lei; Sturgis, Erich M; Zhang, Yang; Huang, Zhigang; Song, Xicheng; Li, Chao; Wei, Qingyi; ... (8 authors) (Molecular cancer, 2013-07-19)
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity, and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic variants may modulate individual susceptibility ...
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AuthorWei, Qingyi (6)Herndon, James E (3)Liu, Zhensheng (3)Sturgis, Erich M (3)Wang, Li-E (3)Fowler, Vance G (2)He, Jing (2)Jin, Lei (2)Jin, Li (2)Li, Guojun (2)... View MoreDate Issued
2013 (19)
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Humans (19)Middle Aged (19)Female (17)Male (17)Adult (16)Aged, 80 and over (11)Young Adult (10)Polymorphism, Single Nucleotide (8)Proportional Hazards Models (5)... View MoreAffiliation of Duke Author(s)
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Institutes and Centers (19)School of Medicine (19)Clinical Science Departments (18)Medicine (15)Duke Cancer Institute (14)Medicine, Medical Oncology (10)Population Health Sciences (9)Biostatistics & Bioinformatics (7)... View More
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