Now showing items 1-10 of 35
Human Vascular Microphysiological System for in vitro Drug Screening.
(Sci Rep, 2016-02-18)
In vitro human tissue engineered human blood vessels (TEBV) that exhibit vasoactivity can be used to test human toxicity of pharmaceutical drug candidates prior to pre-clinical animal studies. TEBVs with 400-800 μM diameters ...
Using electronic health record data for substance use Screening, Brief Intervention, and Referral to Treatment among adults with type 2 diabetes: Design of a National Drug Abuse Treatment Clinical Trials Network study.
(Contemp Clin Trials, 2016-01)
BACKGROUND: The Affordable Care Act encourages healthcare systems to integrate behavioral and medical healthcare, as well as to employ electronic health records (EHRs) for health information exchange and quality improvement. ...
Invited Commentary: Lessons for Research on Cognitive Aging From a Study of Children
(American Journal of Epidemiology, 2016-06-15)
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.
(Sci Rep, 2016-06-01)
TRPV4 ion channels represent osmo-mechano-TRP channels with pleiotropic function and wide-spread expression. One of the critical functions of TRPV4 in this spectrum is its involvement in pain and inflammation. However, few ...
Variability of the IFN-γ ELISpot assay in the context of proficiency testing and bridging studies.
(J Immunol Methods, 2016-06)
Assays that assess cellular mediated immune responses performed under Good Clinical Laboratory Practice (GCLP) guidelines are required to provide specific and reproducible results. Defined validation procedures are required ...
Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.
(Rejuvenation Res, 2016-06)
On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes ...
Genetic Characterization of a Panel of Diverse HIV-1 Isolates at Seven International Sites.
(PLoS One, 2016)
HIV-1 subtypes and drug resistance are routinely tested by many international surveillance groups. However, results from different sites often vary. A systematic comparison of results from multiple sites is needed to determine ...
X-Ray Psoralen Activated Cancer Therapy (X-PACT).
(PLoS One, 2016)
This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative ...
A Systematic Review of Conceptual Frameworks of Medical Complexity and New Model Development.
(J Gen Intern Med, 2016-03)
BACKGROUND: Patient complexity is often operationalized by counting multiple chronic conditions (MCC) without considering contextual factors that can affect patient risk for adverse outcomes. OBJECTIVE: Our objective was ...
Prevalence and correlates of proteinuria in Kampala, Uganda: a cross-sectional pilot study.
(BMC Res Notes, 2016-02-16)
BACKGROUND: Despite the increasing prevalence of chronic kidney disease (CKD) in sub-Saharan Africa, few community-based screenings have been conducted in Uganda. Opportunities to improve the management of CKD in sub-Saharan ...