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Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.
(PloS one, 2017-01)
In mammals, monoallelic gene expression can result from X-chromosome inactivation,
genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation
of RMAE is not fully understood. Here we analyze allelic ...
Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats.
(Journal of neurophysiology, 2017-07)
We have determined the impact of rod death and cone reorganization on the spatiotemporal
receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell
(RGC) types. We compared RGC function between healthy ...
A craniofacial-specific monosynaptic circuit enables heightened affective pain.
(Nature neuroscience, 2017-12)
Humans often rank craniofacial pain as more severe than body pain. Evidence suggests
that a stimulus of the same intensity induces stronger pain in the face than in the
body. However, the underlying neural circuitry for ...
Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee.
(Retrovirology, 2017-06-02)
Simian immunodeficiency virus of chimpanzees (SIVcpz), the progenitor of human immunodeficiency
virus type 1 (HIV-1), is associated with increased mortality and AIDS-like immunopathology
in wild-living chimpanzees ...
Increased renal dopamine and acute renal adaptation to a high-phosphate diet.
(American journal of physiology. Renal physiology, 2011-05)
The current experiments explore the role of dopamine in facilitating the acute increase
in renal phosphate excretion in response to a high-phosphate diet. Compared with a
low-phosphate (0.1%) diet for 24 h, mice ...
Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.
(Immunity, 2018-01)
Despite recent advances, many cancers remain refractory to available immunotherapeutic
strategies. Emerging evidence indicates that the tolerization of local dendritic cells
(DCs) within the tumor microenvironment promotes ...
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
(Nature communications, 2015-04-13)
The plasticity of differentiated cells in adult tissues undergoing repair is an area
of intense research. Pulmonary alveolar type II cells produce surfactant and function
as progenitors in the adult, demonstrating ...
First virtual endocasts of adapiform primates.
(Journal of human evolution, 2016-10)
Well-preserved crania of notharctine adapiforms from the Eocene of North America provide
the best direct evidence available for inferring neuroanatomy and encephalization
in early euprimates (crown primates). Virtual endocasts ...
Predicting euarchontan body mass: A comparison of tarsal and dental variables.
(American journal of physical anthropology, 2015-07)
Multiple meaningful ecological characterizations of a species revolve around body
mass. Because body mass cannot be directly measured in extinct taxa, reliable body
mass predictors are needed. Many published body mass prediction ...
Quantification of the position and depth of the flexor hallucis longus groove in euarchontans, with implications for the evolution of primate positional behavior.
(American journal of physical anthropology, 2017-06)
On the talus, the position and depth of the groove for the flexor hallucis longus
tendon have been used to infer phylogenetic affinities and positional behaviors of
fossil primates. This study quantifies aspects of the flexor ...