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Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.
(BMC cancer, 2010-08-16)
Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving
in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms
may affect survival outcomes among locally advanced ...
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.
(Diabetes, 2010-09)
OBJECTIVE: The orexigenic gut hormone ghrelin and its receptor are present in pancreatic
islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin
secretion in humans has not been established. ...
Effects of FOXO genotypes on longevity: a biodemographic analysis.
(J Gerontol A Biol Sci Med Sci, 2010-12)
Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese),
this article contributes biodemographic insights and syntheses concerning the magnitude
of effects of the FOXO genotypes on longevity. We ...
Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.
(Hypertension, 2010-06)
High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction.
Although aerobic exercise and dietary modifications have been shown to reduce blood
pressure, no randomized trials have examined ...
Pinning down response inhibition in the brain--conjunction analyses of the Stop-signal task.
(Neuroimage, 2010-10-01)
Successful behavior requires a finely-tuned interplay of initiating and inhibiting
motor programs to react effectively to constantly changing environmental demands.
One particularly useful paradigm for investigating inhibitory ...
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Comparative analyses of seven algorithms for copy number variant identification from single nucleotide polymorphism arrays.
(Nucleic Acids Res, 2010-05)
Determination of copy number variants (CNVs) inferred in genome wide single nucleotide
polymorphism arrays has shown increasing utility in genetic variant disease associations.
Several CNV detection methods are available, ...
Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer.
(BMC Cancer, 2010-10-06)
BACKGROUND: The Exercise Intensity Trial (EXcITe) is a randomized trial to compare
the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity
aerobic training, relative to attention control, ...
Prevalence of renal anomalies after urinary tract infections in hospitalized infants less than 2 months of age.
(J Perinatol, 2010-04)
OBJECTIVE: Our aim was to determine the incidence of anatomical abnormalities after
a urinary tract infection (UTI) in infants <2 months of age hospitalized in the neonatal
intensive care unit (NICU). STUDY DESIGN: This ...
Blood lead levels among pregnant women: historical versus contemporaneous exposures.
(Int J Environ Res Public Health, 2010-04)
Blood lead among pregnant women, even at modest levels, may impair offspring cognitive
development. We examine whether blood lead levels (BLLs) result from current versus
historic exposures, among a cohort of pregnant women. ...