Now showing items 111-118 of 118
Extraordinary Claims Require Extraordinary Evidence
(Journal of Health Economics, 2005)
Middle Pliocene sea surface temperature variability
Randomized trial of sertraline versus venlafaxine XR in major depression: Efficacy and discontinuation symptoms
(Journal of Clinical Psychiatry, 2005)
Background: The comparative efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) was recently debated. Meta-analyses, based mainly on fluoxetine comparator ...
Discursive and political deployments by/of the 2002 Palestinian women suicide bombers/martyrs
(Feminist Review, 2005-11-01)
This paper focuses on representations by and deployments of the four Palestinian women who during the first four months of 2002 killed themselves in organized attacks against Israeli military personnel or civilians in the ...
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
(Nature chemical biology, 2005-07)
The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ...
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
(Science (New York, N.Y.), 2005-02)
Most protein phosphatases have little intrinsic substrate specificity, making selective pharmacological inhibition of specific dephosphorylation reactions a challenging problem. In a screen for small molecules that protect ...
Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
(Bioorganic & medicinal chemistry letters, 2005-09)
The synthesis and structure-activity relationships (SAR) of salubrinal, a small molecule that protects cells from apoptosis induced by endoplasmic reticulum (ER) stress, are described. It is revealed that the trichloromethyl ...