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TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.

Yuan, Xianglin; Wei, Qingyi; Komaki, Ritsuko; Liu, Zhensheng; Yang, Ju; Tucker, Susan L; Xu, Ting; ... (11 authors) (PloS one, 2013-01)

Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis. We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated with overall survival (OS) and distant metastasis-free ...

MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.

Song, Xicheng; Sturgis, Erich M; Liu, Jun; Jin, Lei; Wang, Zhongqiu; Zhang, Caiyun; Wei, Qingyi; ... (8 authors) (PloS one, 2013-01)

Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation ...

Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

Guan, Xiaoxiang; Wang, Li-E; Liu, Zhensheng; Sturgis, Erich M; Wei, Qingyi (Journal of cellular and molecular medicine, 2013-07)

Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings. The present ...

ERCC1 and ERCC2 variants predict survival in gastric cancer patients.

Li, Yangkai; Liu, Zhensheng; Liu, Hongliang; Wang, Li-E; Tan, Dongfeng; Ajani, Jaffer A; Wei, Qing-Yi (PloS one, 2013-01)

PURPOSE: ERCC1 and ERCC2 play critical roles in the nucleotide excision repair pathway that effectively repairs DNA damage induced by chemotherapeutic agents. Therefore, functional single nucleotide polymorphisms (SNPs) ...

Effect of socioeconomic status as measured by education level on survival in breast cancer clinical trials.

Herndon, James E; Kornblith, Alice B; Holland, Jimmie C; Paskett, Electra D (Psychooncology, 2013-02)

OBJECTIVES: This paper aims to investigate the effect of socioeconomic status, as measured by education, on the survival of breast cancer patients treated on 10 studies conducted by the Cancer and Leukemia Group B. METHODS: ...

Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.

Ahn, Sun Hee; Tsalik, Ephraim L; Cyr, Derek D; Zhang, Yurong; van Velkinburgh, Jennifer C; Langley, Raymond J; Glickman, Seth W; ... (18 authors) (PLoS One, 2013)

Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ...

A phase I study of ABT-510 plus bevacizumab in advanced solid tumors.

Uronis, Hope E; Cushman, Stephanie M; Bendell, Johanna C; Blobe, Gerard C; Morse, Michael A; Nixon, Andrew B; Dellinger, Andrew; ... (13 authors) (Cancer Med, 2013-06)

Targeting multiple regulators of tumor angiogenesis have the potential to improve treatment efficacy. Bevacizumab is a monoclonal antibody directed against vascular endothelial growth factor and ABT-510 is a synthetic analog ...

Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone.

Sung, AD; Grima, DT; Bernard, LM; Brown, S; Carrum, G; Holmberg, L; Horwitz, ME; ... (13 authors) (Bone Marrow Transplant, 2013-11)

Chemotherapy plus G-CSF (C+G) and G-CSF alone are two of the most common methods used to mobilize CD34(+) cells for autologous hematopoietic SCT (AHSCT). In order to compare and determine the real-world outcomes and costs ...

Provider specialty and atrial fibrillation treatment strategies in United States community practice: findings from the ORBIT-AF registry.

Fosbol, Emil L; Holmes, DaJuanicia N; Piccini, Jonathan P; Thomas, Laine; Reiffel, James A; Mills, Roger M; Kowey, Peter; ... (11 authors) (J Am Heart Assoc, 2013-07-18)

BACKGROUND: The prevalence of atrial fibrillation (AF) continues to increase; however, there are limited data describing the division of care among practitioners in the community and whether care differs depending on provider ...