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Now showing items 11-20 of 108
A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.
(BMC Infect Dis, 2014-02-13)
BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus
infection, and research suggests that there is a genetic basis for this variability.
Several recent genome-wide association studies (GWAS) ...
Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records.
(BMC Infect Dis, 2014-05-22)
BACKGROUND: Mortality among people with human immunodeficiency virus (HIV) infection
is increasingly due to non-communicable causes. This has been observed mostly in developed
countries and the routine care of HIV infected ...
Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...
Left ventricular dysfunction screening in hypertensive patients with N-terminal pro-B-type natriuretic peptide and electrocardiogram.
(Am J Emerg Med, 2012-01)
OBJECTIVE: Early recognition of left ventricular hypertrophy is important because
antihypertensive treatment decreases morbidity and mortality. The ideal screening
method for left ventricular hypertrophy in hypertensive ...
Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.
(PLoS Genet, 2009-01)
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD).
We have previously identified genetic linkage to familial CAD in the genomic region
of NPY. We performed follow-up genetic, biostatistical, ...
Factors associated with isolated right heart failure in women: a pilot study from western Kenya.
(Glob Heart, 2014-06)
BACKGROUND: Small observational studies have found that isolated right heart failure
(IRHF) is prevalent among women of sub-Saharan Africa. Further, several risk factors
for the development of IRHF have been identified. ...
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.
(Am Heart J, 2015-04)
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients
with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis.
Platelet hyperactivity is an important factor in ...
Sex-based differences in outcomes after percutaneous coronary intervention for acute myocardial infarction: a report from TRANSLATE-ACS.
(J Am Heart Assoc, 2014-02-07)
BACKGROUND: Data regarding sex-based outcomes after percutaneous coronary intervention
(PCI) for myocardial infarction are mixed. We sought to examine whether sex differences
in outcomes exist in contemporary practice. METHODS ...
Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.
(BMJ Open, 2015-05-06)
OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial
infarction (MI) or, conversely, those displaying either intrinsic cardioprotective
phenotypes or highly responsive to protective interventions ...