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Now showing items 11-18 of 18
MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.
(PloS one, 2013-01)
Both microRNAs and human papillomavirus (HPV) infection play an important role in
the development and progression of oral squamous cell carcinoma (OSCC). In addition,
microRNAs affect all facets of the immune/inflammation ...
Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.
(Journal of cellular and molecular medicine, 2013-07)
Recently, several studies have investigated the association between a newly reported
rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer
risk, but generated inconsistent findings. The present ...
Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
(BMC cancer, 2016-02-08)
FAS/FASL promoter variants are considered in altering transcriptional activity of
those genes and consequently alter regulation of cell death. However, no studies have
investigated whether tumor sites contribute ...
Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.
(BMC cancer, 2012-05)
The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and
myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human
papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...
Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
(PloS one, 2012-01)
p53 and p73 interact with human papillomavirus (HPV) E6 and E7 oncoproteins. The interplay
between p53 and p73 and HPV16 may lead to deregulation of cell cycle and apoptosis,
through which inflammation/immune responses control ...
Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma.
(PloS one, 2012-01)
The p14(ARF)/MDM2/p53 pathway plays an important role in modulation of DNA damage
and oxidative stress responses. The aim of this study was to determine whether genetic
variants in MDM2 and p14(ARF) are associated with risk ...
Mouse double minute 4 variants modify susceptibility to risk of recurrence in patients with squamous cell carcinoma of the oropharynx.
(Molecular carcinogenesis, 2018-03)
Given the crucial role of Mouse double minute 4 (MDM4) oncoprotein in p53 pathway,
single nucleotide polymorphisms (SNPs) could serve as such biomarkers for prediction
of SCCOP recurrence. Thus, we investigated associations ...
Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck.
(Molecular carcinogenesis, 2018-06)
Squamous cell carcinoma of head and neck (SCCHN) is one of the most common malignancies
worldwide, and nucleotide excision repair (NER) is involved in SCCHN susceptibility.
In this analysis of 349 newly diagnosed SCCHN patients ...