Now showing items 11-20 of 173
Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells.
(BMC Microbiol, 2009-02-03)
BACKGROUND: Pseudomonas aeruginosa is the major pathogen associated with chronic and ultimately fatal lung infections in patients with cystic fibrosis (CF). To investigate how P. aeruginosa-derived vesicles may contribute ...
Characterising phase variations in MALDI-TOF data and correcting them by peak alignment.
(Cancer Inform, 2005)
The use of MALDI-TOF mass spectrometry as a means of analyzing the proteome has been evaluated extensively in recent years. One of the limitations of this technique that has impeded the development of robust data analysis ...
Analysis of case-control association studies: SNPs, imputation and haplotypes
(Statistical Science, 2009)
Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.
Functional MRI was used to investigate the role of medial temporal lobe and inferior frontal lobe regions in autobiographical recall. Prior to scanning, participants generated cue words for 50 autobiographical memories and ...
A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection
Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study.
(BMC Genet, 2005-12-30)
Association studies of quantitative traits have often relied on methods in which a normal distribution of the trait is assumed. However, quantitative phenotypes from complex human diseases are often censored, highly skewed, ...
Liability issues for data monitoring committee members.
(Clin Trials, 2004)
In randomized clinical trials, a data monitoring committee (DMC) is often appointed to review interim data to determine whether there is early convincing evidence of intervention benefit, lack of benefit or harm to study ...
Do smokers respond to health shocks?
(Review of Economics and Statistics, 2001-11-01)
This paper reports the first effort to use data to evaluate how new information, acquired through exogenous health shocks, affects people's longevity expectations. We find that smokers react differently to health shocks ...
A functional analysis of the spacer of V(D)J recombination signal sequences.
(PLoS Biol, 2003-10)
During lymphocyte development, V(D)J recombination assembles antigen receptor genes from component V, D, and J gene segments. These gene segments are flanked by a recombination signal sequence (RSS), which serves as the ...
Issues in regulatory guidelines for data monitoring committees.
(Clin Trials, 2004)
As clinical trials have emerged as the major research method for evaluating new interventions, the process for monitoring intervention safety and benefit has also evolved. The Data Monitoring Committee (DMC) has become the ...