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Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.

Wei, Qingyi; Liu, Zhensheng; Guan, Xiaoxiang; Wang, Li-E; Sturgis, Erich M (Journal of cellular and molecular medicine, 2013-07)

Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings. The present ...

Polymorphisms of nucleotide excision repair genes predict melanoma survival.

Wei, Qingyi; Li, Chunying; Yin, Ming; Wang, Li-E; Amos, Christopher I; Zhu, Dakai; Lee, Jeffrey E; ... (9 authors) (The Journal of investigative dermatology, 2013-07)

Melanoma is the most highly malignant skin cancer, and nucleotide excision repair (NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients, we evaluated whether genetic variants of NER genes ...

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

Wei, Qingyi; McKay, James D; Truong, Therese; Gaborieau, Valerie; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, Graham; ... (129 authors) (PLoS genetics, 2011-03-17)

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved ...

ERCC1 and ERCC2 variants predict survival in gastric cancer patients.

Wei, Qingyi; Liu, Zhensheng; Li, Yangkai; Liu, Hongliang; Wang, Li-E; Tan, Dongfeng; Ajani, Jaffer A (PloS one, 2013-01)

PURPOSE: ERCC1 and ERCC2 play critical roles in the nucleotide excision repair pathway that effectively repairs DNA damage induced by chemotherapeutic agents. Therefore, functional single nucleotide polymorphisms (SNPs) ...