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Now showing items 11-20 of 71

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RAD52 variants predict platinum resistance and prognosis of cervical cancer. 

Shi, Ting-Yan; Yang, Gong; Tu, Xiao-Yu; Yang, Jing-Min; Qian, Ji; Wu, Xiao-Hua; Zhou, Xiao-Yan; ... (9 authors) (PloS one, 2012-01)
RAD52 is an important but not well characterized homologous recombination repair gene that can bind to single-stranded DNA ends and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. ...
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Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial. 

Zhou, Fei; Li, Ning; Jiang, Weihua; Hua, Zhaolai; Xia, Lin; Wei, Qingyi; Wang, Liwei (World journal of surgical oncology, 2012-01)
BACKGROUND: HER-2/neu-targeted therapy has been successfully used in advanced gastric cancer, but the role of HER-2/neu in the prognosis of gastric cancer is not yet clear. In this study, we investigated the correlation ...
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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 

McKay, James D; Truong, Therese; Gaborieau, Valerie; Chabrier, Amelie; Chuang, Shu-Chun; Byrnes, Graham; Zaridze, David; ... (130 authors) (PLoS genetics, 2011-03-17)
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved ...
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A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma. 

Sampson, John H; Schmittling, Robert J; Archer, Gary E; Congdon, Kendra L; Nair, Smita K; Reap, Elizabeth A; Desjardins, Annick; ... (16 authors) (PLoS One, 2012)
BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) ...
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A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer. 

Tao, Ye; Sturgis, Erich M; Huang, Zhigang; Sun, Yan; Dahlstrom, Kristina R; Wei, Qingyi; Li, Guojun (International journal of cancer, 2018-09)
TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with ...
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Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx. 

Wang, Chengyuan; Sturgis, Erich M; Chen, Xingming; Zheng, Hongliang; Wei, Qingyi; Li, Guojun (Oncotarget, 2016-05)
Functional polymorphisms of miRNAs may affect the function and target expression of miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis of cancer. We hypothesized that four common polymorphisms ...
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Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population. 

Zhou, Fei; Cheng, Lei; Qiu, Li-Xin; Wang, Meng-Yun; Li, Jin; Sun, Meng-Hong; Yang, Ya-Jun; ... (11 authors) (Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially functional single nucleotide ...
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A functional variant at miRNA-122 binding site in IL-1a 3' UTR predicts risk of recurrence in patients with oropharyngeal cancer. 

Wang, Chengyuan; Sturgis, Erich M; Chen, Xingming; Wei, Qingyi; Li, Guojun (Oncotarget, 2016-06)
IL-1a, an important regulator of immune and inflammation responses, has been implicated in cancer development and prognosis. An insertion (Ins)/deletion (Del) polymorphism (IL-1a rs3783553) in the 3' UTR of IL-1a may disrupt ...
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Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy. 

Chen, Xingming; Sturgis, Erich M; Wang, Chengyuan; Cao, Xiaoli; Li, Yuncheng; Wei, Qingyi; Li, Guojun (Oncotarget, 2016-06)
Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions and their target expression and thus may affect biological activities and cancer etiology as well as prognosis. Thus, we determined whether ...
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A pri-miR-218 variant and risk of cervical carcinoma in Chinese women. 

Shi, Ting-Yan; Chen, Xiao-Jun; Zhu, Mei-Ling; Wang, Meng-Yun; He, Jing; Yu, Ke-Da; Shao, Zhi-Ming; ... (12 authors) (BMC cancer, 2013-01-15)
BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few ...
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AuthorWei, Qingyi (51)Liu, Zhensheng (16)Sturgis, Erich M (16)Jin, Li (15)Wang, Li-E (14)Li, Guojun (13)He, Jing (12)Wang, Jiu-Cun (12)Sun, Meng-Hong (11)Wei, Qing-Yi (11)... View MoreDate Issued2012 (17)2013 (13)2016 (12)2018 (10)2011 (7)2014 (4)2015 (4)2010 (2)2017 (1)2019 (1)TypeJournal article (71)Subject
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