Search
Now showing items 11-20 of 22
Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation.
(Br J Cancer, 2006-10-23)
Elevated intratumoral interstitial fluid pressure (IFP) and tumour hypoxia are independent
predictive factors for poor survival and poor treatment response in cancer patients.
However, the relationship between IFP and tumour ...
Common genetic variation and the control of HIV-1 in humans.
(PLoS Genet, 2009-12)
To extend the understanding of host genetic determinants of HIV-1 control, we performed
a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
The study was powered to detect common genetic variants ...
Gender differences in the risk of HIV infection among persons reporting abstinence, monogamy, and multiple sexual partners in northern Tanzania.
(PLoS One, 2008-08-27)
BACKGROUND: Monogamy, together with abstinence, partner reduction, and condom use,
is widely advocated as a key behavioral strategy to prevent HIV infection in sub-Saharan
Africa. We examined the association between the ...
A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation.
(Health Qual Life Outcomes, 2004-05-06)
BACKGROUND: Anticoagulation can reduce quality of life, and different models of anticoagulation
management might have different impacts on satisfaction with this component of medical
care. Yet, to our knowledge, there are ...
Early versus delayed fixed dose combination abacavir/lamivudine/zidovudine in patients with HIV and tuberculosis in Tanzania.
(AIDS Res Hum Retroviruses, 2009-12)
Fixed dose combination abacavir/lamivudine/zidovudine (ABC/3TC/ZDV) among HIV-1 and
tuberculosis (TB)-coinfected patients was evaluated and outcomes between early vs.
delayed initiation were compared. In a randomized, pilot ...
Gene expression signatures that predict radiation exposure in mice and humans.
(PLoS Med, 2007-04)
BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is
limited by methods that can accurately and quantitatively measure these contributions.
One such example can be seen in the context of exposure ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB)
gene expression profiling for the detection of disease or environmental exposures.
METHODS AND FINDINGS: We have sought to determine the ...
Age-specific differences in oncogenic pathway deregulation seen in human breast tumors.
(PLoS One, 2008-01-02)
PURPOSE: To define the biology driving the aggressive nature of breast cancer arising
in young women. EXPERIMENTAL DESIGN: Among 784 patients with early stage breast cancer,
using prospectively-defined, age-specific cohorts ...
Comorbidity, age, race and stage at diagnosis in colorectal cancer: a retrospective, parallel analysis of two health systems.
(BMC Cancer, 2008-11-25)
BACKGROUND: Stage at diagnosis plays a significant role in colorectal cancer (CRC)
survival. Understanding which factors contribute to a more advanced stage at diagnosis
is vital to improving overall survival. Comorbidity, ...
Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis.
(Br J Cancer, 2008-01-29)
The aim of this study was to determine the efficacy of palliative oxygen for relief
of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled
trials, comparing oxygen and medical air in cancer ...