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Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method. 

Flahiff, Charlene M; Kraus, Virginia B; Huebner, Janet L; Setton, Lori A (Osteoarthritis and cartilage, 2004-05)
To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis.Cartilage-bone samples from the medial femoral condyle and tibial plateau of 12 month-old guinea pig ...
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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 

Noma, Takahisa; Lemaire, Anthony; Naga Prasad, Sathyamangla V; Barki-Harrington, Liza; Tilley, Douglas G; Chen, Juhsien; Le Corvoisier, Philippe; ... (11 authors) (J Clin Invest, 2007-09)
Deleterious effects on the heart from chronic stimulation of beta-adrenergic receptors (betaARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl ...
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In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. 

Shah, AS; White, DC; Emani, S; Kypson, AP; Lilly, RE; Wilson, K; Glower, DD; ... (9 authors) (Circulation, 2001-03-06)
BACKGROUND: Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed to determine the feasibility and functional consequences of in vivo ...

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 

Meloni, Alison R; Fralish, Gregory B; Kelly, Patrick; Salahpour, Ali; Chen, James K; Wechsler-Reya, Robert J; Lefkowitz, Robert J; ... (8 authors) (Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...
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Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. 

Tachibana, Hideo; Naga Prasad, Sathyamangla V; Lefkowitz, Robert J; Koch, Walter J; Rockman, Howard A (Circulation, 2005-02-08)
BACKGROUND: Heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased level of myocardial betaAR kinase 1 (betaARK1). Our previous studies have shown that inhibition ...
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When 7 transmembrane receptors are not G protein-coupled receptors. 

Rajagopal, Keshava; Lefkowitz, Robert J; Rockman, Howard A (J Clin Invest, 2005-11)
Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein-independent ...
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Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 

Kohout, TA; Takaoka, H; McDonald, PH; Perry, SJ; Mao, L; Lefkowitz, RJ; Rockman, HA (Circulation, 2001-11-13)
BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its ...
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An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. 

Ait-Azzouzene, Djemel; Verkoczy, Laurent; Peters, Jorieke; Gavin, Amanda; Skog, Patrick; Vela, José Luis; Nemazee, David (J Exp Med, 2005-03-07)
Understanding immune tolerance mechanisms is a major goal of immunology research, but mechanistic studies have generally required the use of mouse models carrying untargeted or targeted antigen receptor transgenes, which ...
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Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. 

White, DC; Hata, JA; Shah, AS; Glower, DD; Lefkowitz, RJ; Koch, WJ (Proc Natl Acad Sci U S A, 2000-05-09)
When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR) signaling system, leading to the loss of cardiac inotropic reserve. betaAR down-regulation and functional ...
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Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. 

Harding, VB; Jones, LR; Lefkowitz, RJ; Koch, WJ; Rockman, HA (Proc Natl Acad Sci U S A, 2001-05-08)
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. ...
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AuthorLefkowitz, Robert J (17)Lefkowitz, RJ (14)Koch, WJ (7)Caron, Marc G (4)Ginsburg, Geoffrey S (3)Luttrell, LM (3)Muramoto, Garrett G (3)Perry, SJ (3)Rockman, HA (3)Rockman, Howard A (3)... View MoreDate Issued2000 (8)2001 (8)2003 (6)2004 (4)2002 (3)2005 (3)2007 (3)2008 (3)2009 (3)2006 (2)TypeJournal article (43)Subject
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Mice (27)Humans (21)Arrestins (15)beta-Arrestins (15)Myocardium (13)Male (12)Signal Transduction (12)Phosphorylation (10)beta-Adrenergic Receptor Kinases (9)... View MoreAffiliation of Duke Author(s)
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