Now showing items 11-16 of 16
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
(Proc Natl Acad Sci U S A, 2002-05-28)
Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting ...
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
(Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...
Beta-arrestin-2 regulates the development of allergic asthma.
(J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...
beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking.
(Proc Natl Acad Sci U S A, 2001-02-13)
The two widely coexpressed isoforms of beta-arrestin (termed beta arrestin 1 and 2) are highly similar in amino acid sequence. The beta-arrestins bind phosphorylated heptahelical receptors to desensitize and target them ...
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins.
(Proc Natl Acad Sci U S A, 2001-12-18)
One aspect of the function of the beta-arrestins is to serve as scaffold or adapter molecules coupling G-protein coupled receptors (GPCRs) to signal transduction pathways distinct from traditional second messenger pathways. ...
Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.
(Circ Res, 2008-07-03)
Atherosclerosis and arterial injury-induced neointimal hyperplasia involve medial smooth muscle cell (SMC) proliferation and migration into the arterial intima. Because many 7-transmembrane and growth factor receptors promote ...