Search
Now showing items 11-20 of 222
Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.
(The Journal of pathology, 2012-01)
Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the
prostate and oestrogen receptor (ER) α is required to mediate this response. Previous
studies utilizing tissue recombination with seminal ...
A fruit in the hand or two in the bush? Divergent risk preferences in chimpanzees and bonobos.
(Biol Lett, 2008-06-23)
Human and non-human animals tend to avoid risky prospects. If such patterns of economic
choice are adaptive, risk preferences should reflect the typical decision-making environments
faced by organisms. However, this approach ...
Differences in the cognitive skills of bonobos and chimpanzees.
(PLoS One, 2010-08-27)
While bonobos and chimpanzees are both genetically and behaviorally very similar,
they also differ in significant ways. Bonobos are more cautious and socially tolerant
while chimpanzees are more dependent on extractive foraging, ...
Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance.
(Circulation, 2000-02-01)
BACKGROUND: Genetic modulation of ventricular function may offer a novel therapeutic
strategy for patients with congestive heart failure. Myocardial overexpression of
beta(2)-adrenergic receptors (beta(2)ARs) has been shown ...
Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
(PLoS One, 2008-04-02)
BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB)
gene expression profiling for the detection of disease or environmental exposures.
METHODS AND FINDINGS: We have sought to determine the ...
Intraspecific variation in semicircular canal morphology-A missing element in adaptive scenarios?
(American journal of physical anthropology, 2019-01)
OBJECTIVES:Recent evidence suggests that the amount of intraspecific variation in
semicircular canal morphology may, itself, be evidence for varying levels of selection
related to locomotor demands. To determine the extent ...
The temporal spectrum of adult mosquito population fluctuations: conceptual and modeling implications.
(PLoS One, 2014)
An improved understanding of mosquito population dynamics under natural environmental
forcing requires adequate field observations spanning the full range of temporal scales
over which mosquito abundance fluctuates in natural ...
Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
(Am J Transplant, 2014-01)
De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated
rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion
using anti-CD3 immunotoxin combined with ...
Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
(Nature communications, 2015-04-13)
The plasticity of differentiated cells in adult tissues undergoing repair is an area
of intense research. Pulmonary alveolar type II cells produce surfactant and function
as progenitors in the adult, demonstrating ...
Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings.
(J Neurosci, 2015-03-18)
This study combines for the first time two major approaches to understanding the function
and structure of neural circuits: large-scale multielectrode recordings, and confocal
imaging of labeled neurons. To achieve this ...