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Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.
(Kidney Int, 2014-12)
Focal segmental glomerulosclerosis (FSGS) is a histological lesion with many causes,
including inherited genetic defects, with significant proteinuria being the predominant
clinical finding at presentation. Mutations in ...
The TALKS study to improve communication, logistical, and financial barriers to live donor kidney transplantation in African Americans: protocol of a randomized clinical trial.
(BMC Nephrol, 2015-10-09)
BACKGROUND: Live donor kidney transplantation (LDKT), an optimal therapy for many
patients with end-stage kidney disease, is underutilized, particularly by African
Americans. Potential recipient difficulties initiating and ...
Safety and efficacy of ledipasvir-sofosbuvir in black patients with hepatitis C virus infection: A retrospective analysis of phase 3 data.
(Hepatology, 2016-02)
UNLABELLED: Black patients chronically infected with genotype 1 hepatitis C virus
(HCV) have historically had lower rates of response to interferon-based treatment
than patients of other races. In the phase 3 ION program, ...
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
(Clin Sci (Lond), 2015-11)
Schistosomiasis is a major cause of portal hypertension worldwide. It associates with
portal fibrosis that develops during chronic infection. The mechanisms by which the
pathogen evokes these host responses remain unclear. ...
Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.
(Int J Dermatol, 2015-01)
Abnormal skin findings are identified in over 90% of human immunodeficiency virus
(HIV)-infected persons globally. A prospective cohort study of HIV-infected patients
with skin complaints commencing antiretroviral therapy ...
Impact of increases in high-density lipoprotein cholesterol on cardiovascular outcomes during the armed forces regression study.
(J Cardiovasc Pharmacol Ther, 2010-12)
INTRODUCTION: high-density lipoprotein (HDL) cholesterol is a well-established inverse
risk factor for cardiovascular disease. The extent to which cardiovascular risk can
be modified through changes in HDL, however, is less ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials.
(J Immunol Methods, 2014-07)
A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples
was created to provide laboratories testing the specimens from human immunodeficiency
virus-1 (HIV-1) vaccine clinical trials the material ...
Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya.
(PLoS One, 2017)
BACKGROUND: Atrial fibrillation (AF) is a major contributor to the global cardiovascular
disease burden. The clinical profile and outcomes of AF patients with valvular heart
diseases in sub-Saharan Africa (SSA) have not ...
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)
Acute respiratory infections caused by bacterial or viral pathogens are among the
most common reasons for seeking medical care. Despite improvements in pathogen-based
diagnostics, most patients receive inappropriate antibiotics. ...