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Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
(Molecular carcinogenesis, 2018-01)
Metzincins are key molecules in the degradation of the extracellular matrix and play
an important role in cellular processes such as cell migration, adhesion, and cell
fusion of malignant tumors, including cutaneous melanoma ...
PhenX RISING: real world implementation and sharing of PhenX measures.
(BMC Med Genomics, 2014-03-20)
BACKGROUND: The purpose of this manuscript is to describe the PhenX RISING network
and the site experiences in the implementation of PhenX measures into ongoing population-based
genomic studies. METHODS: Eighty PhenX measures ...
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans.
(Diabetes, 2010-09)
OBJECTIVE: The orexigenic gut hormone ghrelin and its receptor are present in pancreatic
islets. Although ghrelin reduces insulin secretion in rodents, its effect on insulin
secretion in humans has not been established. ...
Steps to Health employee weight management randomized control trial: short-term follow-up results.
(J Occup Environ Med, 2015-02)
OBJECTIVE: To present the short-term follow-up findings of the Steps to Health study,
a randomized trial to evaluate the effectiveness of two employee weight management
programs offered within Duke University and the Health ...
Small-fiber neuropathy in pompe disease: first reported cases and prospective screening of a clinic cohort.
(Am J Case Rep, 2015-04-03)
BACKGROUND: Prior autopsy reports demonstrate glycogen deposition in Schwann cells
of the peripheral nerves in patients with infantile and late-onset Pompe disease (LOPD),
but little is known about associated clinical features. ...
Does surgery improve outcomes for esophageal squamous cell carcinoma? An analysis using the surveillance epidemiology and end results registry from 1998 to 2008.
(J Am Coll Surg, 2012-11)
BACKGROUND: We examined survival associated with locally advanced esophageal squamous
cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate.
STUDY DESIGN: Patients in the Surveillance, ...
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.
(Kidney Int, 2015-10)
Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since
prior studies have supported a genetic basis for postoperative AKI, we conducted a
genome-wide association study (GWAS) for AKI following ...
Effects of FOXO genotypes on longevity: a biodemographic analysis.
(J Gerontol A Biol Sci Med Sci, 2010-12)
Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese),
this article contributes biodemographic insights and syntheses concerning the magnitude
of effects of the FOXO genotypes on longevity. We ...
Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure.
(Hypertension, 2010-06)
High blood pressure increases the risks of stroke, dementia, and neurocognitive dysfunction.
Although aerobic exercise and dietary modifications have been shown to reduce blood
pressure, no randomized trials have examined ...
Randomized trial on mindfulness training for smokers targeted to a disadvantaged population.
(Subst Use Misuse, 2014-04)
We report the results of a randomized trial comparing a novel smoking cessation treatment
Mindfulness Training for Smokers (MTS) to a usual care therapy (Controls), which included
the availability of a tobacco quit line ...