Now showing items 21-30 of 97
The PsychENCODE project.
(Nat Neurosci, 2015-12)
Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques.
(PLoS Pathog, 2015-08)
HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies ...
Transmission of MRSA between companion animals and infected human patients presenting to outpatient medical care facilities.
(PLoS One, 2011)
Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in both human and veterinary medicine. The importance of companion animals as reservoirs of human infections is currently unknown. The companion ...
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.
(J Clin Invest, 2015-01)
Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific ...
Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.
(Eur J Clin Microbiol Infect Dis, 2012-09)
Species of Candida frequently cause life-threatening infections in neonates, transplant and intensive care unit (ICU) patients, and others with compromised host defenses. The successful management of systemic candidiasis ...
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
(J Clin Invest, 2013-09)
Cancers subvert the host immune system to facilitate disease progression. These evolved immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic strategies. Emerging data indicate that ...
The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.
(Sci Rep, 2012)
G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice ...
Strategies for treating latent multiple-drug resistant tuberculosis: a decision analysis.
(PLoS One, 2012)
BACKGROUND: The optimal treatment for latent multiple-drug resistant tuberculosis infection remains unclear. In anticipation of future clinical trials, we modeled the expected performance of six potential regimens for treatment ...
Brucellosis among hospitalized febrile patients in northern Tanzania.
(Am J Trop Med Hyg, 2012-12)
Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a ≥ 4-fold increase in ...
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
A major challenge for the development of a highly effective AIDS vaccine is the identification of mechanisms of protective immunity. To address this question, we used a nonhuman primate challenge model with simian ...