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Now showing items 21-30 of 117
Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial.
(World journal of surgical oncology, 2012-01)
BACKGROUND: HER-2/neu-targeted therapy has been successfully used in advanced gastric
cancer, but the role of HER-2/neu in the prognosis of gastric cancer is not yet clear.
In this study, we investigated the correlation ...
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
(PLoS genetics, 2011-03-17)
Genome-wide association studies (GWAS) have been successful in identifying common
genetic variation involved in susceptibility to etiologically complex disease. We
conducted a GWAS to identify common genetic variation involved ...
Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.
(Infect Control Hosp Epidemiol, 2010-07)
OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive
Staphylococcus aureus infection following 4 types of major surgical procedures.design.
Retrospective cohort study. SETTING: Eleven hospitals ...
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
(PLoS One, 2012)
BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion
of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity
interleukin-2 (IL-2) receptor (IL-2Rα/CD25) ...
Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps.
(Int J Cancer, 2012-07-15)
High levels of circulating insulin-like growth factor-1 (IGF-1) have been associated
with increased risk of several cancers. Regarding colorectal cancer, these associations
are generally weak. We hypothesized that an increase ...
Predictors of latent tuberculosis treatment initiation and completion at a U.S. public health clinic: a prospective cohort study.
(BMC Public Health, 2012-06-21)
BACKGROUND: Treatment of latent tuberculosis infection (LTBI) is a key component in
U.S. tuberculosis control, assisted by recent improvements in LTBI diagnostics and
therapeutic regimens. Effectiveness of LTBI therapy, ...
Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.
(PloS one, 2019-01)
BACKGROUND:The heart is a metabolically active organ, and plasma acylcarnitines are
associated with long-term risk for myocardial infarction. We hypothesized that myocardial
ischemia from cardiac stress testing will produce ...
Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx.
(Oncotarget, 2016-05)
Functional polymorphisms of miRNAs may affect the function and target expression of
miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis
of cancer. We hypothesized that four common polymorphisms ...
Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated
cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially
functional single nucleotide ...
A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.
(Arthritis Res Ther, 2016-04-12)
BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our
objective was to explore the relationships of GlycA, a measure of glycosylated acute
phase proteins, with inflammation and cardiometabolic ...