Now showing items 21-30 of 177
A functional analysis of the spacer of V(D)J recombination signal sequences.
(PLoS Biol, 2003-10)
During lymphocyte development, V(D)J recombination assembles antigen receptor genes from component V, D, and J gene segments. These gene segments are flanked by a recombination signal sequence (RSS), which serves as the ...
A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes.
(Proc Natl Acad Sci U S A, 2006-10-10)
Songbirds have one of the most accessible neural systems for the study of brain mechanisms of behavior. However, neuroethological studies in songbirds have been limited by the lack of high-throughput molecular resources ...
The feeling of looking.
(Nat Neurosci, 2007-05)
Shared features in the pathobiology of babesiosis and malaria.
(Trends Parasitol, 2007-12)
The pathobiology of malaria has been extensively studied in humans but many questions remain, especially regarding fulminant disease associated with Plasmodium falciparum infection. Babesiosis, recognized since biblical ...
Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
(J Exp Med, 2004-01-05)
Inflammation removes developing and mature lymphocytes from the bone marrow (BM) and induces the appearance of developing B cells in the spleen. BM granulocyte numbers increase after lymphocyte reductions to support a reactive ...
A pathway in primate brain for internal monitoring of movements.
It is essential to keep track of the movements we make, and one way to do that is to monitor correlates, or corollary discharges, of neuronal movement commands. We hypothesized that a previously identified pathway from brainstem ...
Frontal eye field sends delay activity related to movement, memory, and vision to the superior colliculus.
(J Neurophysiol, 2001-04)
Many neurons within prefrontal cortex exhibit a tonic discharge between visual stimulation and motor response. This delay activity may contribute to movement, memory, and vision. We studied delay activity sent from the frontal ...
Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
(Int J Nanomedicine, 2009)
A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. ...
Consensus nomenclature for the human ArfGAP domain-containing proteins.
(J Cell Biol, 2008-09-22)
At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has ...
Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2.
(J Exp Med, 2000-11-06)
The complement system enhances antibody responses to T-dependent antigens, but paradoxically, deficiencies in C1 and C4 are strongly linked to autoantibody production in humans. In mice, disruption of the C1qa gene also ...