Now showing items 31-40 of 49
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
(Proc Natl Acad Sci U S A, 2001-05-08)
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. ...
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.
(Proc Natl Acad Sci U S A, 2002-05-28)
Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting ...
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
(Proc Natl Acad Sci U S A, 2004-08-10)
Epithelial Na(+) channels mediate the transport of Na across epithelia in the kidney, gut, and lungs and are required for blood pressure regulation. They are inhibited by ubiquitin protein ligases, such as Nedd4 and Nedd4-2, ...
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
(Journal of Clinical Investigation, 2004-05-15)
Using decision analysis to improve malaria control policy making.
(Health Policy, 2009-10)
Malaria and other vector-borne diseases represent a significant and growing burden in many tropical countries. Successfully addressing these threats will require policies that expand access to and use of existing control ...
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
(J Neurosci, 2004-05-12)
Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [kappa opioid receptor ...
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
(Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein Smoothened regulates cellular proliferation ...
Catecholamines, cardiac beta-adrenergic receptors, and heart failure.
Beta-arrestin-2 regulates the development of allergic asthma.
(J Clin Invest, 2003-08)
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory function ...
The toxicology of climate change: environmental contaminants in a warming world.
(Environ Int, 2009-08)
Climate change induced by anthropogenic warming of the earth's atmosphere is a daunting problem. This review examines one of the consequences of climate change that has only recently attracted attention: namely, the effects ...