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Now showing items 31-40 of 163
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.
(Am Heart J, 2015-04)
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients
with ischemic heart disease (IHD) and associated with a poorer cardiovascular prognosis.
Platelet hyperactivity is an important factor in ...
Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.
(BMJ Open, 2015-05-06)
OBJECTIVES: Identification of patient subpopulations susceptible to develop myocardial
infarction (MI) or, conversely, those displaying either intrinsic cardioprotective
phenotypes or highly responsive to protective interventions ...
A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study.
(BMC Infect Dis, 2014-05-23)
BACKGROUND: Staphylococcus aureus bacteremia is a common infection associated with
significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide
active against Gram-positive pathogens, including ...
Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
(Clin Sci (Lond), 2015-11)
Schistosomiasis is a major cause of portal hypertension worldwide. It associates with
portal fibrosis that develops during chronic infection. The mechanisms by which the
pathogen evokes these host responses remain unclear. ...
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms.
(Breast Cancer Res Treat, 2011-07)
The observed bimodal patterns of breast cancer incidence in the U.S. suggested that
breast cancer may be viewed as more than one biological entity. We studied the factors
potentially contributing to this phenomenon, specifically ...
Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.
(PLoS One, 2013)
Given the importance of cardiovascular disease (CVD) to public health and the demonstrated
heritability of both disease status and its related risk factors, identifying the
genetic variation underlying these susceptibilities ...
Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials.
(J Immunol Methods, 2014-07)
A large repository of cryopreserved peripheral blood mononuclear cells (PBMCs) samples
was created to provide laboratories testing the specimens from human immunodeficiency
virus-1 (HIV-1) vaccine clinical trials the material ...
Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study.
(PLoS One, 2014)
BACKGROUND: While the majority of healthcare in the US is provided in community hospitals,
the epidemiology and treatment of bloodstream infections in this setting is unknown.
METHODS AND FINDINGS: We undertook this multicenter, ...