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Now showing items 31-40 of 42
Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.
(Virology, 2015-01-15)
Simian-human immunodeficiency viruses (SHIVs) that mirror natural transmitted/founder
(T/F) viruses in man are needed for evaluation of HIV-1 vaccine candidates in nonhuman
primates. Currently available SHIVs contain HIV-1 ...
Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.
(Nature, 2015-03-19)
After stimulation, dendritic cells (DCs) mature and migrate to draining lymph nodes
to induce immune responses. As such, autologous DCs generated ex vivo have been pulsed
with tumour antigens and injected back into patients ...
Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice.
(PLoS One, 2010-08-17)
BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to result from stimulation
of immune responses against resident intestinal bacteria within a genetically susceptible
host. Mast cells may play a critical role ...
CD20 deficiency in humans results in impaired T cell-independent antibody responses.
(J Clin Invest, 2010-01)
CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs
are commonly used for the treatment of B cell malignancies and autoantibody-mediated
autoimmune diseases. Despite this the role of CD20 ...
Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.
(Am J Transplant, 2012-10)
Even though the etiology of chronic rejection (CR) is multifactorial, donor specific
antibody (DSA) is considered to have a causal effect on CR development. Currently
the antibody-mediated mechanisms during CR are poorly ...
Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
(Am J Transplant, 2014-01)
De novo donor-specific antibody (DSA) after organ transplantation promotes antibody-mediated
rejection (AMR) and causes late graft loss. Previously, we demonstrated that depletion
using anti-CD3 immunotoxin combined with ...
Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism.
(PLoS One, 2011)
Normally, neutrophil pools are maintained by homeostatic mechanisms that require the
transcription factor C/EBPα. Inflammation, however, induces neutrophilia through a
distinct pathway of "emergency" granulopoiesis that ...
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.
(PLoS One, 2010-06-16)
Medications that can mitigate against radiation injury are limited. In this study,
we investigated the ability of recombinant human growth hormone (rhGH) to mitigate
against radiation injury in mice and nonhuman primates. ...
Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.
(PLoS One, 2010-06-28)
The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine
receptors plays an important role in hematopoiesis following hematopoietic stem cell
transplantation. We examined the efficacy of post transplant ...
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
(PLoS pathogens, 2016-12-02)
Type III secretion systems (T3SS) are central virulence factors for many pathogenic
Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host
cell signaling. To counter this, innate immune responses ...