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Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens.
(J Virol, 2016-04)
UNLABELLED: In a follow-up to the modest efficacy observed in the RV144 trial, researchers
in the HIV vaccine field seek to substantiate and extend the results by evaluating
other poxvirus vectors and combinations with DNA ...
Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
(J Biol Chem, 2016-05-06)
TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory
neurons; however, the contribution of the channel in either cell to neurosensory function
remains to be elucidated. We recently reported TRPV4 ...
Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection.
(PLoS Pathog, 2010-03-12)
Natural killer (NK) cells play an essential role in innate immune control of poxviral
infections in vivo. However, the mechanism(s) underlying NK cell activation and function
in response to poxviruses remains poorly understood. ...
Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.
(PLoS One, 2010-06-28)
The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine
receptors plays an important role in hematopoiesis following hematopoietic stem cell
transplantation. We examined the efficacy of post transplant ...
Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles.
(PLoS One, 2010-07-12)
In the event of a terrorist-mediated attack in the United States using radiological
or improvised nuclear weapons, it is expected that hundreds of thousands of people
could be exposed to life-threatening levels of ionizing ...
EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma.
(PLoS One, 2014)
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and
is uniformly lethal. T-cell-based immunotherapy offers a promising platform for treatment
given its potential to specifically target tumor ...
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
(J Clin Invest, 2013-09)
Cancers subvert the host immune system to facilitate disease progression. These evolved
immunosuppressive mechanisms are also implicated in circumventing immunotherapeutic
strategies. Emerging data indicate that ...
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.
(J Exp Med, 2013-02-11)
Many human monoclonal antibodies that neutralize multiple clades of HIV-1 are polyreactive
and bind avidly to mammalian autoantigens. Indeed, the generation of neutralizing
antibodies to the 2F5 and 4E10 epitopes of HIV-1 ...
Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys.
(J Virol, 2013-10)
The design of an effective vaccine to reduce the incidence of mother-to-child transmission
(MTCT) of human immunodeficiency virus (HIV) via breastfeeding will require identification
of protective immune responses that block ...
Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys.
(J Virol, 2013-10)
Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs),
rarely transmit SIV via breast-feeding. In order to examine the genetic diversity
of breast milk SIV variants in this limited-transmission ...