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Now showing items 31-40 of 171
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...
Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma.
(Cancer Epidemiol Biomarkers Prev, 2015-07)
BACKGROUND: The Notch signaling pathway is constitutively activated in human cutaneous
melanoma to promote growth and aggressive metastatic potential of primary melanoma
cells. Therefore, genetic variants in Notch pathway ...
HPV16 antibodies as risk factors for oropharyngeal cancer and their association with tumor HPV and smoking status.
(Oral Oncol, 2015-07)
BACKGROUND: Antibodies (Abs) to the HPV16 proteome increase risk for HPV-associated
OPC (HPVOPC). The goal of this study was to investigate the association of a panel
of HPV16 Abs with risk for OPC as well as the association ...
Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
(Int J Cancer, 2015-11-15)
Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may
alter their transcriptional activity. Thus, we determined the associations between
four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; ...
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
(Ann Epidemiol, 2015-08)
PURPOSE: Familial clustering of longevity is well documented and includes both genetic
and other familial factors, but the specific underlying mechanisms are largely unknown.
We examined whether low incidence of specific ...
Validation of ICDPIC software injury severity scores using a large regional trauma registry.
(Inj Prev, 2015-10)
BACKGROUND: Administrative or quality improvement registries may or may not contain
the elements needed for investigations by trauma researchers. International Classification
of Diseases Program for Injury Categorisation ...
Torsemide versus furosemide in heart failure patients: insights from Duke University Hospital.
(J Cardiovasc Pharmacol, 2015-05)
Furosemide has historically been the primary loop diuretic in heart failure patients
despite data suggesting potential advantages with torsemide. We used the Duke Echocardiography
Lab Database to investigate patients admitted ...
Specialist and primary care physicians' views on barriers to adequate preparation of patients for renal replacement therapy: a qualitative study.
(BMC Nephrol, 2015-03-28)
BACKGROUND: Early preparation for renal replacement therapy (RRT) is recommended for
patients with advanced chronic kidney disease (CKD), yet many patients initiate RRT
urgently and/or are inadequately prepared. METHODS: ...
Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity.
(Cereb Cortex, 2015-04)
The reliable neuroimaging finding that older adults often show greater activity (over-recruitment)
than younger adults is typically attributed to compensation. Yet, the neural mechanisms
of over-recruitment in older adults ...
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
(Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of
apoptosis and the transformation and progression of malignant cells. Genetic variations
in KIF1B may contribute to risk of epithelial ovarian ...