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Now showing items 31-40 of 131
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
(PLoS One, 2012)
OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma
metabolic intermediates in response to a mixed meal, suggestive of changes in the
capacity to adapt fuel oxidation to fuel availability or ...
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
(PLoS One, 2012)
BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion
of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity
interleukin-2 (IL-2) receptor (IL-2Rα/CD25) ...
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.
(PLoS Med, 2009-07-07)
BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately
2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally
do not become detectable until 12 weeks ...
Feasibility and willingness-to-pay for integrated community-based tuberculosis testing.
(BMC Infect Dis, 2011-11-02)
BACKGROUND: Community-based screening for TB, combined with HIV and syphilis testing,
faces a number of barriers. One significant barrier is the value that target communities
place on such screening. METHODS: Integrated ...
Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication.
(J Virol, 2012-06)
CD8-mediated virus inhibition can be detected in HIV-1-positive subjects who naturally
control virus replication. Characterizing the inhibitory function of CD8(+) T cells
during acute HIV-1 infection (AHI) can elucidate ...
Pilot study of myocardial ischemia-induced metabolomic changes in emergency department patients undergoing stress testing.
(PloS one, 2019-01)
BACKGROUND:The heart is a metabolically active organ, and plasma acylcarnitines are
associated with long-term risk for myocardial infarction. We hypothesized that myocardial
ischemia from cardiac stress testing will produce ...
C-reactive protein, fibrinogen, and cardiovascular disease prediction.
(The New England journal of medicine, 2012-10)
There is debate about the value of assessing levels of C-reactive protein (CRP) and
other biomarkers of inflammation for the prediction of first cardiovascular events.We
analyzed data from 52 prospective studies that included ...
Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx.
(Oncotarget, 2016-05)
Functional polymorphisms of miRNAs may affect the function and target expression of
miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis
of cancer. We hypothesized that four common polymorphisms ...
Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population.
(Oncotarget, 2016-05)
The interleukin-6 (IL-6)/JAK/STAT3 signaling pathway plays a central role in inflammation-mediated
cancers, including gastric cancer (GCa). We evaluated associations between 10 potentially
functional single nucleotide ...
Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy.
(Oncotarget, 2016-06)
Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions
and their target expression and thus may affect biological activities and cancer etiology
as well as prognosis. Thus, we determined whether ...