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Now showing items 31-40 of 192
Angiotensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact.
(J Card Fail, 2015-09)
Heart failure (HF) is an increasingly common syndrome associated with high mortality
and economic burden, and there has been a paucity over the past decade of new pharmacotherapies
that improve outcomes. However, recent ...
Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.
(Arthritis Res Ther, 2012-04-17)
INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical
OA models often focus on joint-level changes. Gait analysis is one method used to
evaluate both preclinical OA models and OA patients. ...
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
(PLoS One, 2013)
Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with
high grade glioma and is routinely used to treat melanoma brain metastases. A prominent
side effect of TMZ is induction of profound lymphopenia, ...
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
(Cancer Cell, 2016-01-11)
The hypoxic tumor microenvironment serves as a niche for maintaining the glioma-initiating
cells (GICs) that are critical for glioblastoma (GBM) occurrence and recurrence. Here,
we report that hypoxia-induced miR-215 is ...
Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia.
(Mol Genet Metab, 2013-06)
Glycogen Storage Disease type Ia (GSD-Ia) in humans frequently causes delayed bone
maturation, decrease in final adult height, and decreased growth velocity. This study
evaluates the pathogenesis of growth failure and the ...
Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.
(PLoS One, 2012)
PURPOSE: To investigate the utility of a liposomal-iodinated nanoparticle contrast
agent and computed tomography (CT) imaging for characterization of primary nodules
in genetically engineered mouse models of non-small cell ...
Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
(PLoS Pathog, 2011-09)
During many chronic infections virus-specific CD8 T cells succumb to exhaustion as
they lose their ability to respond to antigenic activation. Combinations of IL-12,
IL-18, and IL-21 have been shown to induce the ...
BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization.
(Cell Res, 2010-04)
BCL2 is best known as a multifunctional anti-apoptotic protein. However, little is
known about its role in cell-adhesive and motility events. Here, we show that BCL2
may play a role in the regulation of cell adhesion, spreading, ...
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
(J Clin Invest, 2015-01)
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine
kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling;
however, the functions of receptor PTPs in ...
Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.
(J Biol Chem, 2016-05-06)
TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory
neurons; however, the contribution of the channel in either cell to neurosensory function
remains to be elucidated. We recently reported TRPV4 ...