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CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections.
(Dis Model Mech, 2015-12)
Visualization of infection and the associated host response has been challenging in
adult vertebrates. Owing to their transparency, zebrafish larvae have been used to
directly observe infection in vivo; however, such larvae ...
Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish.
(Neurotoxicol Teratol, 2016-01)
Acute exposures to some individual polycyclic aromatic hydrocarbons (PAHs) and complex
PAH mixtures are known to cause cardiac malformations and edema in the developing
fish embryo. However, the heart is not the only organ ...
Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease.
(J Gene Med, 2010-11)
BACKGROUND: Lysosomal storage disorders such as Pompe disease can be more effectively
treated, if immune tolerance to enzyme or gene replacement therapy can be achieved.
Alternatively, immune responses against acid α-glucosidase ...
The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.
(J Immunol, 2011-10-15)
T cell activation leads to engagement of cellular metabolic pathways necessary to
support cell proliferation and function. However, our understanding of the signal
transduction pathways that regulate metabolism and their ...
Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood.
(Eur J Clin Microbiol Infect Dis, 2012-09)
Species of Candida frequently cause life-threatening infections in neonates, transplant
and intensive care unit (ICU) patients, and others with compromised host defenses.
The successful management of systemic candidiasis ...
Strategies for treating latent multiple-drug resistant tuberculosis: a decision analysis.
(PLoS One, 2012)
BACKGROUND: The optimal treatment for latent multiple-drug resistant tuberculosis
infection remains unclear. In anticipation of future clinical trials, we modeled the
expected performance of six potential regimens for treatment ...
Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage.
(PLoS One, 2012)
The phenotype of somatic cells has recently been found to be reversible. Direct reprogramming
of one cell type into another has been achieved with transduction and over expression
of exogenous defined transcription factors ...
Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease.
(Hum Gene Ther, 2012-05)
Pompe disease can be treated effectively, if immune tolerance to enzyme replacement
therapy (ERT) with acid α-glucosidase (GAA) is present. An adeno-associated viral
(AAV) vector carrying a liver-specific regulatory cassette ...
Characterization of a canine model of glycogen storage disease type IIIa.
(Dis Model Mech, 2012-11)
Glycogen storage disease type IIIa (GSD IIIa) is an autosomal recessive disease caused
by deficiency of glycogen debranching enzyme (GDE) in liver and muscle. The disorder
is clinically heterogeneous and progressive, and ...
Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.
(PLoS One, 2010-06-16)
Medications that can mitigate against radiation injury are limited. In this study,
we investigated the ability of recombinant human growth hormone (rhGH) to mitigate
against radiation injury in mice and nonhuman primates. ...