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Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma.
(Leukemia, 2017-03)
PRDM1/BLIMP-1, a master regulator of plasma-cell differentiation, is frequently inactivated
in activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) patients. Little
is known about its genetic aberrations and ...
Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.
(PloS one, 2012-01)
BACKGROUND: Non-Hodgkin's lymphoma (NHL) has been reported to be associated with autoimmune
and pro-inflammatory response, and genetic polymorphisms of candidate genes involved
in autoimmune and pro-inflammatory response ...
Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.
(Respiratory research, 2005-01)
BACKGROUND: The heat shock proteins (Hsps) are induced by stresses such as allergic
factors and inflammatory responses in bronchi epithelial cells and therefore may be
detectable in patients with asthma. However, the etiologic ...
Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease.
(Diabetes care, 2012-05)
Disordered mineral metabolism is a common complication of chronic kidney disease (CKD)
and a novel risk factor for CKD progression, cardiovascular disease, and mortality.
Although diabetes is the leading cause of CKD and ...
Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.
(Journal of clinical oncology : official journal of the American Society of Clinical
Oncology, 2012-10)
PURPOSE: Approximately 5% of diffuse large B-cell lymphomas (DLBCLs) are double-hit
lymphomas (DHLs) with translocations of both MYC and BCL2. DHLs are characterized
by poor outcome. We tested whether DLBCLs with high expression ...
Neuroticism Increases PTSD Symptom Severity by Amplifying the Emotionality, Rehearsal, and Centrality of Trauma Memories.
(Journal of personality, 2017-10)
OBJECTIVE:Although it is well established that neuroticism increases the risk of posttraumatic
stress disorder (PTSD), little is known about the mechanisms that promote PTSD in
individuals with elevated levels of neuroticism. ...
Automatic Vagus Nerve Stimulation Triggered by Ictal Tachycardia: Clinical Outcomes and Device Performance--The U.S. E-37 Trial.
(Neuromodulation : journal of the International Neuromodulation Society, 2016-02)
The Automatic Stimulation Mode (AutoStim) feature of the Model 106 Vagus Nerve Stimulation
(VNS) Therapy System stimulates the left vagus nerve on detecting tachycardia. This
study evaluates performance, safety of the AutoStim ...
CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study.
(Blood, 2013-04)
CD30, originally identified as a cell-surface marker of Reed-Sternberg and Hodgkin
cells of classical Hodgkin lymphoma, is also expressed by several types of non-Hodgkin
lymphoma, including a subset of diffuse large B-cell ...
Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.
(Journal of experimental & clinical cancer research : CR, 2009-06-30)
Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these
genes are involved in tumor growth and progression including angiogenesis, dissemination,
and invasiveness, we hypothesized that ...
Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.
(Oncotarget, 2016-05)
The JNK and P38α pathways play a crucial role in tissue homeostasis, apoptosis and
autophagy under genotoxic stresses, but it is unclear whether single nucleotide polymorphisms
(SNPs) of genes in these pathways play a role ...