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Provider specialty and atrial fibrillation treatment strategies in United States community practice: findings from the ORBIT-AF registry.
(J Am Heart Assoc, 2013-07-18)
BACKGROUND: The prevalence of atrial fibrillation (AF) continues to increase; however,
there are limited data describing the division of care among practitioners in the
community and whether care differs depending on provider ...
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)
BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition
with estimated 30% mortality. Clinical outcomes for patients with severe infections
improve when antibiotics are appropriately chosen ...
Early adoption of dabigatran and its dosing in US patients with atrial fibrillation: results from the outcomes registry for better informed treatment of atrial fibrillation.
(J Am Heart Assoc, 2013-11-25)
BACKGROUND: Dabigatran is a novel oral anticoagulant approved for thromboprophylaxis
in atrial fibrillation. Adoption patterns of this new agent in community practice
are unknown. METHODS AND RESULTS: We studied patterns ...
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)
Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and
uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature
suggests the host's inflammatory response to the ...
Biomarkers to help guide management of patients with pulmonary nodules.
(Am J Respir Crit Care Med, 2013-08-15)
RATIONALE: Indeterminate pulmonary nodules are a common radiographic finding and require
further evaluation because of the concern for lung cancer. OBJECTIVES: We developed
an algorithm to assign patients to a low- or high-risk ...
Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.
(Journal of cellular and molecular medicine, 2013-07)
Recently, several studies have investigated the association between a newly reported
rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer
risk, but generated inconsistent findings. The present ...
TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.
(PloS one, 2013-01)
Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis.
We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated
with overall survival (OS) and distant metastasis-free ...
Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few
studies have evaluated associations between functional ...
Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma.
(Molecular cancer, 2013-07-19)
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity,
and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic
variants may modulate individual susceptibility ...
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
(The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair
(NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients,
we evaluated whether genetic variants of NER genes ...