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Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
(Mol Cell Biol, 2006-10)
Deregulation of the Sonic hedgehog pathway has been implicated in an increasing number
of human cancers. In this pathway, the seven-transmembrane (7TM) signaling protein
Smoothened regulates cellular proliferation ...
Trafficking of G protein-coupled receptors.
(Circ Res, 2006-09-15)
G protein-coupled receptors (GPCRs) play an integral role in the signal transduction
of an enormous array of biological phenomena, thereby serving to modulate at a molecular
level almost all components of human biology. ...