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    In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. 

    Emani, S; Glower, Donald D Jr; Koch, Walter J; Kypson, Alan P; Lefkowitz, Robert J; Lilly, R Eric; Shah, AS; ... (9 authors) (Circulation, 2001-03-06)
    BACKGROUND: Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed to determine the feasibility and functional consequences of in vivo ...
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    beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. 

    Huang, J; Hupfeld, CJ; Imamura, T; Lefkowitz, Robert J; Olefsky, JM; Satoh, H; Shenoy, SK; ... (8 authors) (Mol Cell Biol, 2004-10)
    beta-arrestin-1 is an adaptor protein that mediates agonist-dependent internalization and desensitization of G-protein-coupled receptors (GPCRs) and also participates in the process of heterologous desensitization between ...
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    beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. 

    Baillie, GS; Gall, I; Houslay, MD; Lefkowitz, Robert J; McPhee, I; Perry, SJ; Sood, A (Proc Natl Acad Sci U S A, 2003-02-04)
    Phosphorylation of the beta(2) adrenoreceptor (beta(2)AR) by cAMP-activated protein kinase A (PKA) switches its predominant coupling from stimulatory guanine nucleotide regulatory protein (G(s)) to inhibitory guanine nucleotide ...
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    Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. 

    Achiriloaie, M; Albanesi, JP; Claing, A; Lefkowitz, Robert J; Perry, SJ; Premont, Richard Thomas; Walker, JK (Proc Natl Acad Sci U S A, 2000-02-01)
    Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled ...
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    Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. 

    Daaka, Y; Lefkowitz, Robert J; Luttrell, LM; Maudsley, S; Pierce, KL (Proc Natl Acad Sci U S A, 2000-02-15)
    Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs) activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade. Recently, it has been shown ...
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    Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. 

    Benovic, JL; Duncan, SJ; Eckhart, AD; Koch, Walter J; Lefkowitz, Robert J; Penn, RB (Circ Res, 2000-01-07)
    G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization. In vivo analysis of GRK substrate selectivity has ...
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    Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. 

    Choy, EW; Field, ME; Lefkowitz, Robert J; Luttrell, LM; Miller, WE; Pierce, KL; Roudabush, FL (Proc Natl Acad Sci U S A, 2001-02-27)
    Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation ...
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    Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 

    Kohout, TA; Lefkowitz, Robert J; Mao, L; McDonald, Patricia H; Perry, SJ; Rockman, Howard A; Takaoka, H (Circulation, 2001-11-13)
    BACKGROUND: Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its ...
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    Regulation of G protein-coupled receptor signaling by scaffold proteins. 

    Hall, RA; Lefkowitz, Robert J (Circ Res, 2002-10-18)
    The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric ...
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    beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. 

    Chen, JR; DeWire, SM; Kovacs, JJ; Lam, CM; Lefkowitz, Robert J; Muehlbauer, Michael J; Shukla, Arun Kumar; ... (10 authors) (J Clin Invest, 2009-05)
    Nicotinic acid is one of the most effective agents for both lowering triglycerides and raising HDL. However, the side effect of cutaneous flushing severely limits patient compliance. As nicotinic acid stimulates the GPCR ...
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    Lefkowitz, Robert J (33)
    Koch, Walter J (9)Rockman, Howard A (6)Caron, MG (4)Luttrell, LM (4)Perry, SJ (4)Glower, Donald D Jr (3)Shah, AS (3)Bohn, LM (2)DeWire, SM (2)... View MoreDate Issued2001 (8)2000 (7)2003 (6)2002 (3)2004 (3)2005 (2)2006 (1)2007 (1)2008 (1)2009 (1)TypeJournal article (33)Subject
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    Mice (20)Arrestins (15)beta-Arrestins (15)Humans (15)Myocardium (12)Signal Transduction (11)beta-Adrenergic Receptor Kinases (9)Cell Line (9)Cyclic AMP-Dependent Protein Kinases (9)... View MoreAffiliation of Duke Author(s)Basic Science Departments (33)Biochemistry (33)Chemistry (33)
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